Document Detail

Effect of recombinant human erythropoietin administration on peripheral blood neutrophil counts of premature infants.
MedLine Citation:
PMID:  8120723     Owner:  NLM     Status:  MEDLINE    
To clarify whether administration of recombinant human erythropoietin (rHuEpo) may have toxic effects on neutrophil production in premature infants, 10 low birth weight infants who received rHuEpo, 200 U/kg per week, were studied retrospectively. Treated infants were compared with 10 untreated infants. None of the infants studied had infection antenatally or postnatally. In both groups the neutrophil count remained greater than 5000/mm3 for the first 3 weeks and decreased markedly at approximately 4 weeks. Although reticulocyte counts were significantly elevated in the rHuEpo-treated group, the difference in neutrophil counts between the groups was not significant. In addition, administration of rHuEpo did not exert any significant effect on granulocyte-macrophage colony formation of circulating hematopoietic progenitors in neonates. Thus no evidence was found that administration of rHuEpo has toxic effects on granulopoiesis in premature infants.
S Mizuno; J Sasaki; C Suzuki; H Kono; S Kojima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  124     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-04-07     Completed Date:  1994-04-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  467-70     Citation Subset:  AIM; IM    
Division of Neonatology, Japanese Red Cross Nagoya First Hospital.
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MeSH Terms
Erythropoietin / administration & dosage,  pharmacology*
Fetal Blood / immunology
Granulocyte-Macrophage Colony-Stimulating Factor / blood
Granulocytes / drug effects
Hematopoietic Stem Cells / drug effects*
Infant, Low Birth Weight / blood
Infant, Newborn
Infant, Premature / blood*,  immunology
Leukocyte Count / drug effects
Macrophages / drug effects
Neutrophils / drug effects*
Recombinant Proteins / administration & dosage,  pharmacology*
Retrospective Studies
Reg. No./Substance:
0/Recombinant Proteins; 11096-26-7/Erythropoietin; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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