Document Detail

Effect of recombinant granulocyte colony-stimulating factor on blood neutrophil concentrations among patients with "idiopathic neonatal neutropenia": a randomized, placebo-controlled trial.
MedLine Citation:
PMID:  13679938     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We previously described a severe, prolonged, idiopathic, but self-resolving, variety of neutropenia among preterm neonates. In the present study, we sought to assess the marrow neutrophil reserves of these patients by serially measuring blood neutrophils following the administration of recombinant granulocyte colony-stimulating factor (rG-CSF) or placebo. STUDY DESIGN: Prospective, randomized trial of rG-CSF vs placebo for infants with "idiopathic neonatal neutropenia". RESULTS: During 36 consecutive months, 2407 neonates were admitted to the neonatal intensive care unit; 429 weighed less than 1500 g at birth, 14 of these were later diagnosed with "idiopathic neonatal neutropenia"; 10 were enrolled in this trial. The five rG-CSF recipients had an immediate, marked increase in blood neutrophil concentration, indicating adequate rG-CSF-mobilizable marrow neutrophil reserves. This effect persisted to day 5, but counts were not different from those of the five placebo recipients on days 12 and 15. CONCLUSIONS: Patients with "idiopathic neonatal neutropenia" have a substantial rG-CSF-mobilizable marrow neutrophil reserve. On that basis, we speculate that this variety of neonatal neutropenia does not constitute a significant deficiency in antibacterial defense.
Sandra E Juul; Robert D Christensen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  23     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-18     Completed Date:  2004-02-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  493-7     Citation Subset:  IM    
Department of Pediatrics, Division of Neonatology, University of Washington, Box 356320, Seattle, WA 98195, USA.
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MeSH Terms
Granulocyte Colony Stimulating Factor, Recombinant / therapeutic use*
Infant, Newborn
Infant, Newborn, Diseases / drug therapy*
Infant, Very Low Birth Weight*
Leukocyte Count
Neutropenia / drug therapy*
Neutrophils* / drug effects
Prospective Studies
Grant Support
Reg. No./Substance:
0/Granulocyte Colony Stimulating Factor, Recombinant

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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