Document Detail


Effect of receptor blockers (methysergide, propranolol, phentolamine, yohimbine and prazosin) on desimipramine-induced pituitary hormone stimulation in humans--I. Growth hormone.
MedLine Citation:
PMID:  3031716     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this report the effects of various receptor blockers on desimipramine (DMI)-induced growth hormone (GH) secretion in healthy male subjects are presented. Each trial consisted of two administrations: one of DMI i.v. alone and one of DMI i.v. in combination with the respective receptor blocker: methysergide (serotonin (5-HT) receptor blocker), propranolol (beta receptor blocker), phentolamine (alpha-1/alpha-2 receptor blocker), yohimbine (alpha-2 greater than alpha-1 receptor blocker), and prazosin (alpha-1 receptor blocker). DMI-induced GH stimulation was not significantly different after DMI i.v. alone (n = 12) than after three days' pretreatment with 12 mg methysergide p.o. in another group of subjects (n = 12). Following combined administration of DMI and propranolol (15 mg i.v.), GH secretion was significantly increased by 25 mg DMI (p less than 0.05) and 50 mg DMI (incomplete block design, n = 18). GH secretion was significantly lower (p less than 0.01) after DMI in combination with 60 mg phentolamine i.v. compared to that after administration of DMI alone in the same group (n = 12). Following 10 mg yohimbine i.v. in combination with DMI (n = 6), the DMI-induced GH increase was also significantly less (p less than 0.05) than that after DMI alone. The DMI-induced GH increase following DMI plus 1 mg prazosin p.o. (n = 12) was comparable to that after DMI alone. The results indicate that the GH-stimulating effect of DMI is primarily related to the ability of DMI to inhibit noradrenaline (NA) reuptake. Should serotonergic receptors be involved in the DMI-induced GH secretion at all, they transmit a positive stimulus. The alpha-1 receptors are most likely not (or not essentially) involved, whereas alpha-2 receptors affect the DMI-induced secretion positively, and beta receptors have an inhibitory effect.
Authors:
G Laakmann; K Zygan; H W Schoen; A Weiss; M Wittmann; R Meissner; D Blaschke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychoneuroendocrinology     Volume:  11     ISSN:  0306-4530     ISO Abbreviation:  Psychoneuroendocrinology     Publication Date:  1986  
Date Detail:
Created Date:  1987-05-04     Completed Date:  1987-05-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7612148     Medline TA:  Psychoneuroendocrinology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  447-61     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Blood Glucose / metabolism
Blood Pressure / drug effects
Carrier Proteins*
Desipramine / pharmacology*
Drug Interactions
Growth Hormone / secretion*
Humans
Male
Methysergide / pharmacology
Phentolamine / pharmacology
Pituitary Hormones / secretion*
Prazosin / pharmacology
Propranolol / pharmacology
Receptors, Drug*
Receptors, Neurotransmitter / metabolism*
Time Factors
Yohimbine / pharmacology
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Carrier Proteins; 0/Pituitary Hormones; 0/Receptors, Drug; 0/Receptors, Neurotransmitter; 0/desipramine receptor; 146-48-5/Yohimbine; 19216-56-9/Prazosin; 361-37-5/Methysergide; 50-47-5/Desipramine; 50-60-2/Phentolamine; 525-66-6/Propranolol; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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