Document Detail

Effect of rapid intravenous crystalloid infusion on uteroplacental blood flow and placental implantation-site oxygen delivery in the pregnant ewe.
MedLine Citation:
PMID:  8498449     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our purpose in this study was to investigate the effects of rapid intravenous crystalloid infusion on placental implantation-site blood flow and oxygen delivery in the near-term pregnant ewe. STUDY DESIGN: Maternal left ventricular, femoral arterial and venous, and bilateral fetal hind limb arterial catheters were placed in nine near-term ewes 5 days before the start of the study. Maternal and fetal arterial blood gas values, maternal hemodynamic measurements, and maternal organ blood flows (microsphere technique) were obtained before and after the intravenous infusion of 2.0 to 2.5 L of normal saline solution. Myometrial and placental implantation-site vascular resistances and oxygen delivery were calculated. The t test for paired comparisons was used for statistical analysis, with p < or = 0.05 considered significant. RESULTS: Significant postinfusion increases in maternal mean arterial pressure, placental implantation-site blood flow, and skin, skeletal muscle, and renal blood flows were recorded. In the six animals that demonstrated a fall in hemoglobin concentration, a significant increase in placental implantation-site oxygen delivery and a significant decrease in placental implantation-site vascular resistance were also seen. No significant changes were seen in myometrial blood flow or myometrial vascular resistance. CONCLUSION: Rapid intravenous crystalloid infusion selectively increases placental implantation-site blood flow in the near-term pregnant ewe and may improve oxygen delivery to the fetus, especially if hemodilution occurs.
J P Crino; A P Harris; V M Parisi; T R Johnson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  168     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-06-22     Completed Date:  1993-06-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1603-9     Citation Subset:  AIM; IM    
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas Medical School, Houston.
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MeSH Terms
Blood Gas Analysis
Infusions, Intravenous
Isotonic Solutions
Oxygen / metabolism*
Placenta / blood supply*,  metabolism
Plasma Substitutes / administration & dosage*,  pharmacology
Regional Blood Flow / drug effects
Rehydration Solutions / administration & dosage*,  pharmacology
Time Factors
Uterus / blood supply*
Reg. No./Substance:
0/Isotonic Solutions; 0/Plasma Substitutes; 0/Rehydration Solutions; 0/crystalloid solutions; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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