Document Detail

Effect of rapid cessation of enzyme replacement therapy: a report of 5 cases and a review of the literature.
MedLine Citation:
PMID:  22926198     Owner:  NLM     Status:  MEDLINE    
CONCLUSIONS: 1. Rapid cessation of ERT results not only in the loss of the beneficial effects, but in a significant worsening of the patient's clinical status. 2. Decisions about the introduction of ERT, especially in patients severely affected, should be made carefully. 3. Once started, it is essential to keep an adequate administration schedule of ERT to maintain the clinical benefits of enzyme therapy.
Agnieszka Jurecka; Zbigniew Żuberuber; Violetta Opoka-Winiarska; Grzegorz Węgrzyn; Anna Tylki-Szymańska
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2012-08-17
Journal Detail:
Title:  Molecular genetics and metabolism     Volume:  107     ISSN:  1096-7206     ISO Abbreviation:  Mol. Genet. Metab.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-29     Completed Date:  2013-03-27     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  9805456     Medline TA:  Mol Genet Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  508-12     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Enzyme Replacement Therapy*
Iduronate Sulfatase / therapeutic use*
Mucopolysaccharidosis II / drug therapy*,  enzymology,  mortality,  pathology
Survival Analysis
Treatment Outcome
Withholding Treatment / ethics,  utilization*
Young Adult
Reg. No./Substance:
EC Sulfatase; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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