| Effect of rapeseed oil-derived plant sterol and stanol esters on atherosclerosis parameters in cholesterol-challenged heterozygous Watanabe heritable hyperlipidaemic rabbits. | |
| | |
MedLine Citation:
|
PMID: 19772679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Rapeseed oil (RSO) is a novel source of plant sterols, containing the unique brassicasterol in concentrations higher than allowed for plant sterol blends in food products in the European Union. Effects of RSO sterols and stanols on aortic atherosclerosis were studied in cholesterol-fed heterozygous Watanabe heritable hyperlipidaemic (Hh-WHHL) rabbits. Four groups (n 18 per group) received a cholesterol-added (2 g/kg) standard chow or this diet with added RSO stanol esters (17 g/kg), RSO stanol esters (34 g/kg) or RSO sterol esters (34 g/kg) for 18 weeks. Feeding RSO stanol esters increased plasma campestanol (P < 0.001) and sitostanol (P < 0.001) and aortic campestanol (P < 0.05) compared with controls. Feeding RSO sterol esters increased concentrations of plasma campesterol (P < 0.001), sitosterol (P < 0.001) and brassicasterol (P < 0.001) and aortic campesterol (P < 0.01). Significantly lower plasma cholesterol (P < 0.001) was recorded in the treated groups after 3 weeks and throughout the study. LDL-cholesterol was reduced 50 % in the high-dose RSO sterol ester (P < 0.01) and high-dose RSO stanol ester (P < 0.001) groups compared with controls. Atherosclerotic lesions were found in three rabbits in each of the RSO stanol ester groups and in one in the RSO sterol ester group. Aortic cholesterol was decreased in the treated groups (P < 0.001) in response to lowering of plasma cholesterol induced by RSO sterol and stanol esters. In conclusion, RSO stanol and sterol esters with a high concentration of brassicasterol were well tolerated. They were hypocholesterolaemic and inhibited experimental atherosclerosis in cholesterol-fed Hh-WHHL rabbits. A significant uptake of plant sterols into the blood and incorporation of campesterol and campestanol into aortic tissue was recorded. |
| | |
Authors:
|
Malene Schrøder; Christiane Fricke; Kirsten Pilegaard; Morten Poulsen; Ingmar Wester; Dieter Lütjohann; Alicja Mortensen |
Related Documents
:
|
3191959 - Steinernema feltiae (= neoaplectana carpocapsae): effect of sterols and hypolipidemic a... 4430879 - In vivo studies of sterol and squalene secretion by human skin. 12763919 - 11-hydroxylation in the biosynthesis of endogenous ouabain: multiple implications. 16207489 - Ester percentages of plant sterols and cholesterol in chylomicrons and vldl of humans w... 2600539 - Increased sitosterol absorption, decreased removal, and expanded body pools compensate ... 6783419 - Regulation of sterol synthesis in human intestinal mucosa. 11397709 - High-fat, high-cholesterol diet increases the incidence of gastritis in ldl receptor-ne... 2524159 - Hormones regulating lipid and carbohydrate metabolism in premenopausal women: modulatio... 9690919 - Characterization of two hdl subfractions and lpa-i, lpa-i:a-ii distribution profiles an... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The British journal of nutrition Volume: 102 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2009-12-16 Completed Date: 2010-01-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
|
Languages: eng Pagination: 1740-51 Citation Subset: IM |
Affiliation:
|
National Food Institute, Technical University of Denmark, Søborg, Denmark. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Aorta / chemistry Atherosclerosis / metabolism, pathology, prevention & control* Cholestadienols / administration & dosage Cholesterol / analogs & derivatives, analysis, blood Cholesterol, Dietary / administration & dosage* Female Heterozygote Hyperlipidemias / diet therapy*, genetics Lipids / blood Male Phytosterols / administration & dosage*, analysis, blood Plant Oils / administration & dosage, chemistry* Rabbits Sitosterols / blood |
| Chemical | |
Reg. No./Substance:
|
0/Cholestadienols; 0/Cholesterol, Dietary; 0/Lipids; 0/Phytosterols; 0/Plant Oils; 0/Sitosterols; 474-60-2/campestanol; 474-62-4/campesterol; 474-67-9/brassicasterol; 57-88-5/Cholesterol; 8002-13-9/rapeseed oil; 83-45-4/stigmastanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Heterotopic cesarean scar pregnancy how should it be managed?
Next Document: Comparison of gut microbiota and allergic reactions in BALB/c mice fed different cultivars of rice.