Document Detail

Effect of rapamycin on the healing of the bile duct.
MedLine Citation:
PMID:  15848547     Owner:  NLM     Status:  MEDLINE    
Besides its potent immunosuppressive properties, rapamycin also has antitumor and antifungal effects. Rapamycin also inhibits the proliferation of fibroblasts and therefore may impair the healing of various tissues. We investigated the effect of rapamycin on the healing of the bile duct anastomosis. The study was undertaken in pigs that were subjected to a laparotomy under general anesthesia. The bile duct was mobilized and divided and immediately reanastomosed. The animals were randomly allocated to receive either rapamycin or placebo. The animals were sacrificed on the postoperative day 5, then the biliary anastomosis was excised and used to determine the tensile strength, hydroxyproline levels, and the histological changes. The tensile strength and the hydroxyproline levels in the biliary anastomosis were lower in the animals treated with rapamycin. The liver function tests were normal. These studies show that rapamycin may impair the healing of the biliary anastomosis.
D Kahn; C W Spearman; A Mall; E Shepherd; G Engelbrecht; Z Lotz; M Tyler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation proceedings     Volume:  37     ISSN:  0041-1345     ISO Abbreviation:  Transplant. Proc.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-04-25     Completed Date:  2005-09-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  832-3     Citation Subset:  IM    
Department of Surgery and the Medical Research Council Liver Research Centre, University of Cape Town, Cape Town, South Africa.
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MeSH Terms
Anastomosis, Surgical*
Bile Ducts / surgery*
Disease Models, Animal
Immunosuppressive Agents / adverse effects
Sirolimus / adverse effects*
Wound Healing / drug effects*
Reg. No./Substance:
0/Immunosuppressive Agents; 53123-88-9/Sirolimus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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