| Effect of ramipril therapy on cognitive functions in cases of mild to moderate essential hypertension. | |
| | |
MedLine Citation:
|
PMID: 17877291 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Several studies have questioned the effect of hypertension on cognitive functions. Event related potentials (P300) have been used as a reliable and reproducible indicator of cognitive functions. In this non-randomized, open label study we investigated cognitive functions using event related potentials in newly diagnosed mild to moderate essential hypertensive patients and whether or not there was any effect of antihypertensive treatment with angiotensin converting enzyme inhibitor ramipril on the event related potentials. We selected twenty male patients of newly diagnosed mild to moderate essential hypertension by using ambulatory blood pressure monitoring who were previously untreated and compared their event related potentials with 10 normotensive controls. At the beginning of the study, the hypertensive group showed increased P300 and N2 wave latency as compared to the normotensive control subjects. After three months of Ramipril therapy at a dose of 5mg per day, there was a significant decrease in all the ambulatory blood pressure parameters and the mean P300 latency from the pretreatment values. But no significant change in the N2 latency was observed. Thus, treatment with Ramipril 5 mg daily for a period of three months can reverse some aspects of cognitive dysfunction associated with hypertension. |
| | |
Authors:
|
Nasreen Qureshi; Rashmi Babbar |
Publication Detail:
|
Type: Clinical Trial; Journal Article |
Journal Detail:
|
Title: Indian journal of physiology and pharmacology Volume: 51 ISSN: 0019-5499 ISO Abbreviation: Indian J. Physiol. Pharmacol. Publication Date: 2007 Jan-Mar |
Date Detail:
|
Created Date: 2007-09-19 Completed Date: 2007-10-09 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0374707 Medline TA: Indian J Physiol Pharmacol Country: India |
Other Details:
|
Languages: eng Pagination: 40-8 Citation Subset: IM |
Affiliation:
|
Department of Physiology, Maulana Azad Medical College, New Delhi. drnasreen2003@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Angiotensin-Converting Enzyme Inhibitors / pharmacology, therapeutic use Blood Pressure / drug effects Blood Pressure Monitoring, Ambulatory / methods Circadian Rhythm Cognition Disorders / complications, drug therapy* Event-Related Potentials, P300 / drug effects Evoked Potentials, Auditory / drug effects Humans Hypertension / complications, drug therapy*, physiopathology Male Middle Aged Ramipril / therapeutic use* Severity of Illness Index Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin-Converting Enzyme Inhibitors; 87333-19-5/Ramipril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hypoglycemic and other related effects of Boswellia glabra in alloxan-induced diabetic rats.
Next Document: Lead acetate induced contraction in rat tracheal smooth muscle is independent of epithelium.