| Effect of ramipril on left ventricular mass in normotensive hemodialysis patients. | |
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MedLine Citation:
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PMID: 16490627 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Normotensive hemodialysis patients may still have left ventricular hypertrophy in the absence of significant pressure or volume overload. We examined the hypothesis that treatment with an angiotensin-converting enzyme inhibitor could be beneficial in the reversal of left ventricular hypertrophy in these patients. METHODS: Forty-six normotensive patients with end-stage renal disease on regular hemodialysis therapy were randomly assigned to administration of ramipril, 2.5 mg 3 times/wk, or placebo for 1 year. Left ventricular mass index and parameters of cardiovascular structure and function were evaluated noninvasively by means of echocardiography and arterial tonometry at baseline, 6 and 12 months after treatment, and 1 month after washout. RESULTS: In the ramipril group, blood pressure decreased significantly at 6 and 12 months after treatment. There were no significant within-group or between-group differences in left ventricular mass index at entry, 6 and 12 months after treatment, and 1 month after washout. There were no significant differences in left atrial dimension, left ventricular size and wall thickness, left ventricular ejection fraction, aortic dimension, intima-media thickness, elastic modulus and augmentation index of the common carotid artery, and aortic pulse wave velocity between the ramipril and placebo groups at entry, 6 and 12 months after treatment, and 1 month after washout. CONCLUSION: A 12-month treatment with ramipril did not cause significant regression of left ventricular hypertrophy in normotensive hemodialysis patients. Results may suggest that the renin-angiotensin system has little role in the pathogenesis of mild left ventricular hypertrophy in these patients. |
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Authors:
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Wen-Chung Yu; Yao-Ping Lin; I-Feng Lin; Shao-Yuan Chuang; Chen-Huan Chen |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of kidney diseases : the official journal of the National Kidney Foundation Volume: 47 ISSN: 1523-6838 ISO Abbreviation: Am. J. Kidney Dis. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-02-21 Completed Date: 2006-04-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8110075 Medline TA: Am J Kidney Dis Country: United States |
Other Details:
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Languages: eng Pagination: 478-84 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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therapeutic use* Double-Blind Method Female Heart Ventricles / drug effects Humans Hypertrophy, Left Ventricular / etiology*, prevention & control* Male Middle Aged Ramipril / therapeutic use* Renal Dialysis / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 87333-19-5/Ramipril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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