| Effect of ramipril on alpha-adrenoceptor-mediated oscillatory contractions in tail artery of hypertensive rats. | |
MedLine Citation:
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PMID: 8281989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent studies indicate that norepinephrine-induced contractile oscillations in the tail artery from stroke-prone spontaneously hypertensive rats (SHRSP) may be a vascular phenomenon independent of blood pressure level. The objectives of this study were: (1) to characterize pharmacologically the alpha-adrenoceptor mediating norepinephrine-induced oscillations in tail artery; and (2) to investigate the relationship between blood pressure level, altered by treatments with hydralazine/hydrochlorothiazide or the angiotensin converting enzyme inhibitor ramipril, and the observation of norepinephrine-induced oscillations in tail artery. The alpha 2-adrenoceptor agonists clonidine and guanabenz potently stimulated oscillatory contractions in the tail artery while the alpha 1-adrenoceptor agonists phenylephrine and methoxamine were considerably less potent. Yohimbine, an alpha 2-adrenoceptor antagonist, but not the alpha 1-adrenoceptor antagonist prazosin demonstrated high affinity for the receptor mediating norepinephrine-induced oscillatory contractions. These results support the hypothesis that norepinephrine-induced oscillatory contractions in the tail artery from SHRSP occur primarily through stimulation of alpha 2-adrenoceptors. Ramipril lowered blood pressure in SHRSP after 4 weeks of treatment during 6-10 weeks of life but did not alter the ability of the alpha 2-adrenoceptor agonist clonidine (10(-5) M) to induce contractile oscillations in tail arteries from SHRSP, indicating these oscillations are not a secondary effect of high blood pressure. These studies suggest that norepinephrine-induced oscillations in tail artery from SHRSP may be a vascular trait separate and distinct from blood pressure level and angiotensin II expression early in life. |
Authors:
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S W Watts; O Traub; F S Lamb; J H Myers; R C Webb |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: European journal of pharmacology Volume: 242 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1994-02-14 Completed Date: 1994-02-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 245-53 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of Michigan, Ann Arbor 48109. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / drug effects Blood Pressure / drug effects Cerebrovascular Disorders / genetics Disease Susceptibility Hypertension / genetics, physiopathology* Muscle, Smooth, Vascular / drug effects Norepinephrine / antagonists & inhibitors, pharmacology Periodicity Ramipril / pharmacology* Rats Rats, Inbred SHR Rats, Inbred WKY Receptors, Adrenergic, alpha / drug effects* Tail / blood supply Vasoconstriction / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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HL-18575/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Adrenergic, alpha; 51-41-2/Norepinephrine; 87333-19-5/Ramipril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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