Document Detail


Effect of raisin consumption on oxidative stress and inflammation in obesity.
MedLine Citation:
PMID:  18355330     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: Oxidative stress can initiate increased inflammation that elevates risk for cardiovascular disease. The objective of this study was to determine the effects of daily consumption of raisins on markers of oxidative stress, inflammation and endothelial activation in response to an acute high-fat meal in overweight individuals. METHODS: Seventeen overweight men and women consumed 90 g raisins or isocaloric placebo (264 kcal/day) for 14 days in a randomized, crossover design while following a low-flavonoid diet. The oxidative [urinary 8-iso-prostaglandin-F(2alpha) (8-epi PGF(2alpha)) and serum oxygen radical absorbance capacity (ORAC)], inflammatory (serum C-reactive protein and interleukin-6), endothelial (serum soluble intercellular adhesion molecule-1 and soluble vascular cell adhesion molecule-1, sVCAM-1) and metabolic [free fatty acids (FFAs), triacylglycerol, glucose and insulin] response to four high-fat (53%) meals was tested pre- and postintervention. RESULTS: Urinary 8-epi PGF(2alpha) decreased (-22%) and fasting ORAC increased (+3%) after both interventions combined. Fasting protein-free ORAC was modestly (+3.5%) higher during the raisin than the placebo intervention. Neither the meals nor the raisins consistently induced fasted markers of inflammation or endothelial dysfunction. Gender influenced postprandial metabolic responses in that males responded with higher serum FFAs, sVCAM-1 and glucose compared with females. CONCLUSIONS: Serum antioxidant capacity was modestly increased by daily raisin consumption, but this did not alter fasted or postprandial inflammatory response in these relatively healthy but overweight individuals. Providing all food in regular pattern reduced measures of oxidative stress.
Authors:
J W Rankin; M C Andreae; C-Y Oliver Chen; S F O'Keefe
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-03-18
Journal Detail:
Title:  Diabetes, obesity & metabolism     Volume:  10     ISSN:  1463-1326     ISO Abbreviation:  Diabetes Obes Metab     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-12-02     Completed Date:  2009-08-20     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  100883645     Medline TA:  Diabetes Obes Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  1086-96     Citation Subset:  IM    
Affiliation:
Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, VA 24061-0430, USA. jrankin@vt.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Biological Markers / blood,  urine
Blood Glucose / analysis
C-Reactive Protein / analysis
Cross-Over Studies
Diet, Reducing*
Dinoprost / analogs & derivatives,  urine
Fatty Acids, Nonesterified / blood
Feeding Behavior
Female
Humans
Inflammation / diet therapy
Intercellular Adhesion Molecule-1 / blood
Interleukin-6 / blood
Male
Obesity / diet therapy*,  immunology,  metabolism
Oxidative Stress*
Phytotherapy*
Postprandial Period
Sex Factors
Vascular Cell Adhesion Molecule-1 / blood
Vitis*
Young Adult
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Interleukin-6; 0/Vascular Cell Adhesion Molecule-1; 126547-89-5/Intercellular Adhesion Molecule-1; 27415-26-5/8-epi-prostaglandin F2alpha; 551-11-1/Dinoprost; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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