Document Detail


Effect of raised alveolar pressure on leukocyte retention in the human lung.
MedLine Citation:
PMID:  2394649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine whether an increase in alveolar pressure delays the passage of leukocytes (WBCs) through the lung by compressing the lung capillaries, we measured the concentration of WBC across the lung in response to a forced expiratory maneuver. In 20 human subjects, blood was sampled from catheters placed in the pulmonary artery (PA) and left ventricle (LV) before, during, and after a forced expiratory maneuver held for greater than or equal to 20 s against an occluded airway. Pressures were recorded at the mouth and from both catheters. A significant fall in LV WBC (P less than 0.01) but not in PA WBC occurred during or immediately after the maneuver in 18 subjects, with a mean maximum decrease of 26 +/- 12% (SD) from base line (range 9-46%). Between 1 and 3 min after the maneuver, there was an increase in LV and PA WBC (P less than 0.01) above base line. The neutrophil and lymphocyte counts showed similar changes, but erythrocyte and platelet counts remained unchanged. The degree of fall in LV WBC correlated closely (r = 0.68, P less than 0.01) with the changes from lung zone 3 to zone 2 and 1 conditions, as determined from the pressure changes. We conclude that WBCs are retained in the lung during a forced expiratory maneuver because of alveolar capillary compression.
Authors:
J Markos; R O Hooper; D Kavanagh-Gray; B R Wiggs; J C Hogg
Related Documents :
10696539 - Effects of intra-uterine growth restriction on the control of breathing and lung develo...
8316799 - Scanning electron microscopy of styrene-methylethylketone casts of the airway and the a...
2920579 - The relationship between lung volume and standard scalar ecg parameters in normal subje...
16424709 - Ventilatory and hemodynamic management of potential organ donors: an observational survey.
3338939 - Efficacy of a hyperinflation and hyperoxygenation suctioning intervention.
15731599 - Vaporized perfluorohexane attenuates ventilator-induced lung injury in isolated, perfus...
15331679 - Vasomotor responses to decreased venous return: effects of cardiac deafferentation in h...
10888569 - High-pressure effects on lysosome integrity and lysosomal enzyme activity in bovine mus...
15994269 - Sleep x 9: an approach to treatment of obstructive sleep apnoea/hypopnoea syndrome incl...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  69     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-10-09     Completed Date:  1990-10-09     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  214-21     Citation Subset:  IM    
Affiliation:
Pulmonary Research Laboratory, University of British Columbia, Vancouver, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Blood Circulation Time
Capillaries / physiology
Female
Humans
Leukocyte Count
Leukocytes / cytology,  physiology*
Male
Middle Aged
Pressure
Pulmonary Alveoli / blood supply,  physiology*
Pulmonary Circulation / physiology*
Valsalva Maneuver / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Systemic vascular reactivity during high-altitude pregnancy.
Next Document:  Radial heat and water transport across the airway wall.