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Effect of quercetin on P-glycoprotein transport ability in Chinese healthy subjects.
MedLine Citation:
PMID:  23422925     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objectives:The aim of this study was to investigate the effect of quercetin on P-glycoprotein (P-gp) transport ability in vivo.Subjects/Methods:Genotype data were available from a total of 165 health volunteers. An open, randomized, two-period crossover clinical trial was performed in eighteen subjects with different MDR1 3435 C/T genotypes. All subjects took 500 mg quercetin or placebo daily from 1st to 13th day or from 43st to 55th day, and 100 mg talinolol was given at the 14th or 56th day. The washout period is 28 days.Results:In this study, we found the values of area under the curve (AUC)(0-48) (h), AUC(0-∞) and C(max) of talinolol in all subjects significantly decreased (6496.6±2389.9 vs 7809.5±2386.8 ng.h/ml, P=0.04), (8414.7±344.8 vs 10478.2±4195.4 ng.h/ml, P=0.03), (412.9±132.6 vs 543.3±97.9 ng.h/ml, P=0.01) after administration of quercetin, respectively. There were no significant differences in t(max) and t(1/2) of talinolol. The results also showed AUC(0-48) (h) (5598.6±2202.1 vs 8229.4±1491.7 ng.h/ml, P=0.02) and AUC(0-∞) (7110.0±3437.0 vs 12681.2±4828.2 ng.h/ml, P=0.01) of talinolol to be significantly decreased in MDR1 3435 TT individuals administered of quercetin. The C(max) of talinolol in MDR1 3435 TT (382.4±149.1 vs 584.9±115.2 ng/ml, P=0.04) and MDR1 3435 CT (383.5±104.9 vs 554.6±80.6 ng/ml, P=0.01) individuals significantly decreased after the administration of quercetin.Conclusions:Quercetin significantly induced the activity of P-gp and this induced effect was more obvious in MDR1 3435 TT individuals.European Journal of Clinical Nutrition advance online publication, 20 February 2013; doi:10.1038/ejcn.2013.5.
Authors:
S-Y Wang; K-M Duan; Y Li; Y Mei; H Sheng; H Liu; X Mei; W Ouyang; H-H Zhou; Z-Q Liu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-20
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  -     ISSN:  1476-5640     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1] Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China [2] Department of Anesthesiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.
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