Document Detail

Effect of the quaternary ammonium compound trospium chloride on 24 hour jejunal motility in healthy subjects.
MedLine Citation:
PMID:  8307445     Owner:  NLM     Status:  MEDLINE    
This study aimed to record 24 hour jejunal motility in healthy ambulant subjects and to analyse changes in motility caused by the oral administration of an anticholinergic agent, the quaternary ammonium compound, trospium chloride. In a placebo-controlled, double blind crossover trial, 24 hour jejunal motility was recorded in 12 healthy volunteers, aged 25 (21-30) years, using a digital data logger connected to two strain-gauge transducers mounted 20 cm apart in a flexible nasojejunal catheter. A computer program was developed to determine contraction parameters. Trospium chloride (15 mg orally thrice daily) prolonged the duration of irregular contractile activity after meals (p < 0.02) and reduced its contraction frequency and amplitude (p < 0.001). In the fasting state, the cycle length of the migrating motor complex was prolonged (p < 0.01) by an extended phase I (p < 0.025). Phase III was shortened (p < 0.005) and showed a slower aboral migration velocity (p < 0.005). Clustered contractions were less frequent during postprandial and fasting periods (p < 0.01). Runs of clustered contractions were completely absent with trospium chloride. Digital manometry was useful for long term recordings of jejunal motility and enabled the motor effects of an anticholinergic agent to be characterised in ambulant subjects.
T Schmidt; R Widmer; A Pfeiffer; H Kaess
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gut     Volume:  35     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-03-15     Completed Date:  1994-03-15     Revised Date:  2013-05-22    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  27-33     Citation Subset:  AIM; IM    
Department of Gastroenterology and Hepatology, Krankenhaus München-Bogenhausen, Munich, Germany.
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MeSH Terms
Ambulatory Care / methods
Circadian Rhythm / physiology
Double-Blind Method
Fasting / physiology
Gastrointestinal Motility / drug effects*
Jejunum / physiology*
Monitoring, Physiologic / methods
Nortropanes / pharmacology*
Parasympatholytics / pharmacology*
Reg. No./Substance:
0/Nortropanes; 0/Parasympatholytics; 1E6682427E/trospium chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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