Document Detail

Effect of pyridine on the hepatic and pulmonary metabolism of 2-butanol in rat and rabbit.
MedLine Citation:
PMID:  8478979     Owner:  NLM     Status:  MEDLINE    
Pyridine has been shown to be an effective inducer of the ethanol-inducible cytochrome P-450IIE1 in both liver and lung. The oxidation of 2-butanol by rat liver is inducible by chronic ethanol consumption. The purpose of this study was to determine the effect of pyridine on the hepatic and pulmonary metabolism of butanol. Comparisons were made between rat and rabbit. Acute pyridine treatment (200 mg/kg, ip) increased hepatic metabolism of 2-butanol in the rat twofold and in the rabbit threefold. The effect of pyridine on hepatic butanol oxidase is similar to the effect reported by other investigators for ethanol administered in the drinking water for 3 wk. Control rabbit pulmonary butanol oxidase activity was 10-fold higher than that in the rat. Pyridine decreased pulmonary butanol oxidase activity in the rabbit. The effect was demonstrated both in vitro and in the isolated perfused rabbit lung. Pyridine had no effect on pulmonary butanol oxidase activity in the rat.
D A Page; G P Carlson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of toxicology and environmental health     Volume:  38     ISSN:  0098-4108     ISO Abbreviation:  J Toxicol Environ Health     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-05-25     Completed Date:  1993-05-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7513622     Medline TA:  J Toxicol Environ Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  369-79     Citation Subset:  IM    
Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907-1334.
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MeSH Terms
Butanols / metabolism*
Liver / drug effects,  metabolism*
Lung / drug effects,  metabolism*
Oxidation-Reduction / drug effects
Oxidoreductases / metabolism
Pyridines / pharmacology*
Rats, Sprague-Dawley
Species Specificity
Grant Support
Reg. No./Substance:
0/Butanols; 0/Pyridines; 110-86-1/pyridine; 78-92-2/2-butanol; EC 1.-/Oxidoreductases

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