Document Detail


Effect of a putative ERalpha antagonist, MPP, on food intake in cycling and ovariectomized rats.
MedLine Citation:
PMID:  19254732     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Estrogens exert many of their behavioral effects by binding to nuclear estrogen receptor (ER) proteins, ERalpha and ERbeta. Recent studies involving ER knockout mice and selective ER agonists suggest that estradiol's anorexigenic effect is mediated via activation of ERalpha. To investigate this hypothesis, we examined whether the presumptive ERalpha antagonist, MPP, could block estradiol's anorexigenic effect. In the first series of experiments, the effects of MPP on food intake and uterine weight were monitored in ovariectomized (OVX) rats treated with either a physiological dose of estradiol benzoate (EB) or a selective ERalpha agonist (PPT). In the final experiment, food intake was monitored following acute administration of MPP in ovarian-intact (cycling) female rats. Contrary to our hypothesis, MPP failed to attenuate either EB's or PPT's ability to decrease food intake and increase uterine weight in OVX rats. However, in ovarian-intact rats, a similar regimen of MPP treatment attenuated the phasic decrease in food intake that is associated with estrus. We conclude that MPP may be a useful tool to investigate the behavioral actions of endogenous estradiol, but may have limited utility in studying the behavioral effects of exogenous estradiol in OVX rats.
Authors:
Jessica Santollo; Lisa A Eckel
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-02-28
Journal Detail:
Title:  Physiology & behavior     Volume:  97     ISSN:  1873-507X     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-20     Completed Date:  2009-08-10     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  193-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
1-Methyl-4-phenylpyridinium / pharmacology*
Animals
Behavior, Animal / drug effects
Body Weight / drug effects
Dose-Response Relationship, Drug
Eating / drug effects*
Estradiol / pharmacology
Estrogen Receptor alpha / agonists,  antagonists & inhibitors*
Female
Ginsenosides / pharmacology
Menstrual Cycle / drug effects*
Organ Size / drug effects
Ovariectomy
Rats
Rats, Long-Evans
Sapogenins / pharmacology
Uterus / anatomy & histology,  drug effects
Grant Support
ID/Acronym/Agency:
DK-073936/DK/NIDDK NIH HHS; NS-062667/NS/NINDS NIH HHS; R01 DK073936/DK/NIDDK NIH HHS; R01 DK073936-03/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Estrogen Receptor alpha; 0/Ginsenosides; 0/Sapogenins; 0/ginsenoside 20S-protopanaxatriol; 4TI98Z838E/Estradiol; R865A5OY8J/1-Methyl-4-phenylpyridinium
Comments/Corrections

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