| Effect of pulsing in low-level light therapy. | |
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MedLine Citation:
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PMID: 20662021 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVE: Low level light (or laser) therapy (LLLT) is a rapidly growing modality used in physical therapy, chiropractic, sports medicine and increasingly in mainstream medicine. LLLT is used to increase wound healing and tissue regeneration, to relieve pain and inflammation, to prevent tissue death, to mitigate degeneration in many neurological indications. While some agreement has emerged on the best wavelengths of light and a range of acceptable dosages to be used (irradiance and fluence), there is no agreement on whether continuous wave or pulsed light is best and on what factors govern the pulse parameters to be chosen. STUDY DESIGN/MATERIALS AND METHODS: The published peer-reviewed literature was reviewed between 1970 and 2010. RESULTS: The basic molecular and cellular mechanisms of LLLT are discussed. The type of pulsed light sources available and the parameters that govern their pulse structure are outlined. Studies that have compared continuous wave and pulsed light in both animals and patients are reviewed. Frequencies used in other pulsed modalities used in physical therapy and biomedicine are compared to those used in LLLT. CONCLUSION: There is some evidence that pulsed light does have effects that are different from those of continuous wave light. However further work is needed to define these effects for different disease conditions and pulse structures. |
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Authors:
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Javad T Hashmi; Ying-Ying Huang; Sulbha K Sharma; Divya Balachandran Kurup; Luis De Taboada; James D Carroll; Michael R Hamblin |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Lasers in surgery and medicine Volume: 42 ISSN: 1096-9101 ISO Abbreviation: Lasers Surg Med Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-27 Completed Date: 2010-12-08 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 8007168 Medline TA: Lasers Surg Med Country: United States |
Other Details:
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Languages: eng Pagination: 450-66 Citation Subset: IM |
Copyright Information:
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(c) 2010 Wiley-Liss, Inc. |
Affiliation:
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Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Animals Brain Ischemia / therapy Cerebral Cortex / metabolism Humans Laser Therapy, Low-Level* / methods Lasers Nerve Regeneration / radiation effects Neural Conduction Pain / therapy Stroke / therapy Wound Healing / radiation effects |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI050875-07/AI/NIAID NIH HHS; R01 AI050875-08/AI/NIAID NIH HHS; R01AI050875/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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56-65-5/Adenosine Triphosphate |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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