Document Detail

Effect of pulsatile and nonpulsatile assist on heart and kidney microcirculation with cardiogenic shock.
MedLine Citation:
PMID:  8817977     Owner:  NLM     Status:  MEDLINE    
To estimate microcirculation of the heart and kidney in pulsatile and nonpulsatile-assisted circulation, a comparison study was done using a swine model. Acute myocardial infarction was made by ligation of the left coronary artery branches. After cardiogenic shock, animals were divided into 3 groups as follows: Group C (n = 6), no assist provided; Group NP (n = 6), assisted by a nonpulsatile pump (Bio-Medicus BP-80); Group P (n = 6), supported by a pulsatile pump (Nippon Zeon). left coronary artery flow, endocardial and epicardial regional flows, and renal cortex and medulla tissue blood flows were measured. Left coronary artery flow and endocardial and epicardial tissue blood flows decreased in cardiogenic shock, and they recovered to the control level soon after support in both Group N and Group P. Renal medulla and cortex tissue blood flows decreased in cardiogenic shock, and these flows did not recover in either Group N or P. However, cortex blood flow in Group P did improve, but it did not improve in Group N. These results suggested that pulsatile assist was more effective than nonpulsatile assist for microcirculation after cardiogenic shock to avoid deterioration of major organ functions.
K Nakata; M Shiono; Y Orime; M Hata; A Sezai; T Saitoh; Y Sezai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Artificial organs     Volume:  20     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-12-11     Completed Date:  1996-12-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  681-4     Citation Subset:  IM    
Second Department of Surgery, nihon University School of Medicine, Tokyo, Japan.
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MeSH Terms
Coronary Circulation / physiology*
Disease Models, Animal
Heart-Assist Devices / adverse effects,  standards*
Kidney Cortex / blood supply,  physiology
Kidney Medulla / blood supply,  physiology
Myocardial Infarction / physiopathology,  therapy
Pulsatile Flow
Renal Circulation / physiology*
Shock, Cardiogenic / blood,  physiopathology,  therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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