| Effect of proxyphylline and benzopyrones on the cerebrocortical NAD/NADH redox state and reflectance in haemorrhagic shock. | |
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MedLine Citation:
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PMID: 219868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of 7-(2-hydroxypropyl)theophylline (proxyphylline) and coumarin (Theokal) on cerebrocortical NAD/NADH redox state and vascular volume was investigated in cats in haemorrhagic shock. The influence of these drugs on cortical NADH and UV reflectance responses induced by nitrogen breathing and electrical stimulation of the cortex was also studied. The results are summarized as follows: 1. Proxyphylline administration does not change the cortical vascular volume but shifts the NAD/NADH redox state towards oxidation. This occurs in spite of the significant arterial blood pressure drop. 2. Coumarin dilates the cerebrocortical vessels and increases the cerebral blood flow. Since NAD reduction was obtained though CBF increased, it is presumed that coumarin increased the rate of glycolysis and the lactate/pyruvate ratio. 3. Proxyphylline increased, coumarin decreased the amplitude of the anoxic NAD reduction. The stimulation induced NAD and reflectance reactions were not effected by coumarin. 4. Finally it is concluded that the beneficial effect of Theokal on brain circulation and metabolism in haemorrhagic shock is related with different mechanisms to both substances, proxyphylline and 5,6-benzo-alpha-pyrone. |
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Authors:
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E Dora; A G Kovách |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Arzneimittel-Forschung Volume: 28 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1978 |
Date Detail:
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Created Date: 1979-06-11 Completed Date: 1979-06-11 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 787-90 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Brain / drug effects, metabolism* Cats Coumarins / pharmacology* Drug Combinations Electric Stimulation Fluorometry NAD / metabolism* Nitrogen / pharmacology Oxidation-Reduction / drug effects Shock, Hemorrhagic / metabolism*, physiopathology Theophylline / analogs & derivatives*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Coumarins; 0/Drug Combinations; 53-84-9/NAD; 58-55-9/Theophylline; 7727-37-9/Nitrogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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