| THE EFFECT OF PROTEIN SOURCE IN DIETS FED DURING GESTATION AND LACTATION ON FOOD INTAKE REGULATION IN MALE OFFSPRING OF WISTAR RATS. | |
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MedLine Citation:
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PMID: 21325647 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We hypothesized that protein source in the nutritionally adequate AIN 93G diets fed during gestation, lactation and weaning, influences food intake (FI) regulation in male offspring of Wistar rats. Pregnant rats were fed either the recommended casein (C) or soy protein (S) diet during gestation (Exp 1) or during gestation and lactation (Exp 2). Pups (n=12/group) weaned to either C or S diets were followed for 9 wks (Exp 1) or for 14 wks (Exp 2). At termination, body weight was higher by 5.4% and 9.4%, respectively in offspring born to S diet fed dams. Altered FI regulation was shown by failure of devazepide (CCK-A receptor blocker) to block FI reduction after protein preloads in rats born to the S diet whereas it had a strong effect on those born to C fed dams (p<0.005). Similarly, naloxone (opioid receptor blocker) blocked FI reduction more after casein than after soy protein preloads (p<0.01). In Exp 2, offspring born to dams fed the S diet had higher hypothalamic gene expression of agouti related protein (AgRP) at weaning (p<0.05) and higher FI was found throughout post-weaning (p<0.0001). FI reduction after protein preloads at wk 7 and after glucose preloads at wk 13 was greater in offspring born to the C diet fed dams (p<0.05). Plasma insulin at weaning and insulin, ghrelin and GLP-1 at wk 15 were higher in those born to the S diet fed dams (all p<0.05). In conclusion, nutritionally complete diets based on casein and soy protein consumed during gestation and lactation differ in their effects on BW and FI regulation in the offspring. Extending the diet from gestation alone to throughout gestation and lactation exaggerated the adverse effects of the S diet. However, the diet consumed post-weaning had little effect on the outcome. |
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Authors:
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Alireza Jahan-Mihan; Chris Smith; G Harvey Anderson |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-16 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: - ISSN: 1522-1490 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Toronto. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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