Document Detail


THE EFFECT OF PROTEIN SOURCE IN DIETS FED DURING GESTATION AND LACTATION ON FOOD INTAKE REGULATION IN MALE OFFSPRING OF WISTAR RATS.
MedLine Citation:
PMID:  21325647     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We hypothesized that protein source in the nutritionally adequate AIN 93G diets fed during gestation, lactation and weaning, influences food intake (FI) regulation in male offspring of Wistar rats. Pregnant rats were fed either the recommended casein (C) or soy protein (S) diet during gestation (Exp 1) or during gestation and lactation (Exp 2). Pups (n=12/group) weaned to either C or S diets were followed for 9 wks (Exp 1) or for 14 wks (Exp 2). At termination, body weight was higher by 5.4% and 9.4%, respectively in offspring born to S diet fed dams. Altered FI regulation was shown by failure of devazepide (CCK-A receptor blocker) to block FI reduction after protein preloads in rats born to the S diet whereas it had a strong effect on those born to C fed dams (p<0.005). Similarly, naloxone (opioid receptor blocker) blocked FI reduction more after casein than after soy protein preloads (p<0.01). In Exp 2, offspring born to dams fed the S diet had higher hypothalamic gene expression of agouti related protein (AgRP) at weaning (p<0.05) and higher FI was found throughout post-weaning (p<0.0001). FI reduction after protein preloads at wk 7 and after glucose preloads at wk 13 was greater in offspring born to the C diet fed dams (p<0.05). Plasma insulin at weaning and insulin, ghrelin and GLP-1 at wk 15 were higher in those born to the S diet fed dams (all p<0.05). In conclusion, nutritionally complete diets based on casein and soy protein consumed during gestation and lactation differ in their effects on BW and FI regulation in the offspring. Extending the diet from gestation alone to throughout gestation and lactation exaggerated the adverse effects of the S diet. However, the diet consumed post-weaning had little effect on the outcome.
Authors:
Alireza Jahan-Mihan; Chris Smith; G Harvey Anderson
Related Documents :
9360007 - Differential accumulation and release of long-chain n-3 fatty acids from liver, muscle,...
20298807 - Marked variability in hepatic expression of cytochromes cyp7a1 and cyp27a1 as compared ...
8381477 - Influence of feeding unsaturated fats on growth and immune status of mice.
15564767 - Effects of psyllium on plasma total and lipoprotein cholesterol and hepatic cholesterol...
9298577 - The role of apoptosis in the modulation of colon carcinogenesis by dietary fat and by t...
17033017 - Developmental and nutritional regulation of the prepubertal bovine mammary gland: ii. e...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-16
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  -     ISSN:  1522-1490     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1University of Toronto.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Neuronostatin acts in brain to biphasically increase mean arterial pressure through sympatho-activat...
Next Document:  Localized {beta}-adrenergic receptor blockade does not affect sweating during exercise.