Document Detail


Effect of a protein meal in stomach and jejunum on gastric secretory response to pentagastrin in cats.
MedLine Citation:
PMID:  3928288     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A humoral gastrin potentiating mechanism was previously demonstrated in the upper intestine of cats. The present study was carried out on 10 cats with a gastric fistula (GF) and a Heidenhain pouch (HP). In five of the cats the duodenum and proximal jejunum were excluded as a Roux-en-Y loop, and the other cats were provided with an isolated jejunal Thirty-Vella loop. In the Roux-en-Y loop cats, a protein-rich oral meal augmented the maximal HP acid response to pentagastrin but not the pepsin response. Protein-rich food in the Thirty-Vella loop did not stimulate acid secretion, nor did it augment the maximal GF or HP acid response to pentagastrin. Previous and present results suggest that an unknown humoral gastrin-potentiating mechanism is activated by a protein-rich meal in the stomach and the duodenum but not in the jejunum. The mechanism potentiates pentagastrin-induced acid, but not pepsin, secretion.
Authors:
M Fernström; S Emås
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  30     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1985-10-04     Completed Date:  1985-10-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  877-83     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cats
Dietary Proteins / pharmacology*
Enteral Nutrition
Gastric Acid / secretion
Gastric Mucosa / secretion*
Gastrins / physiology
Jejunum
Pentagastrin / pharmacology*
Pepsin A / metabolism
Chemical
Reg. No./Substance:
0/Dietary Proteins; 0/Gastrins; 5534-95-2/Pentagastrin; EC 3.4.23.1/Pepsin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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