Document Detail

Effect of protein intake on erythropoiesis during erythropoietin treatment of anemia of prematurity.
MedLine Citation:
PMID:  8618185     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the effect of protein intake on the erythropoietic response of very low birth weight infants to treatment with recombinant human erythropoietin (rHuEPO). STUDY DESIGN: Twenty very low birth weight infants were enrolled in the study and 19 completed the 6 weeks of study. Weekly absolute reticulocyte counts, protein intakes, and growth, as well as selected markers of protein metabolism--prealbumin, albumin, and transferrin--were analyzed. Iron stores were estimated for each infant to exclude iron deficiency as a cause of anemia. The relationship between protein intake and absolute reticulocyte count was evaluated with a linear breakpoint analysis to account for any plateau in the relationship at higher protein intakes. RESULTS: Adequate iron stores were present in all infants, and transferrin concentrations correlated with measured total iron-binding capacity (r = 0.95, p = 0.0001). In the rHuEPO-treated infants, absolute reticulocyte count was significantly associated with protein intake up to 3.1 gm/kg per day and extending to 3.5 gm/kg per day (p = 0.041 to 0.032); beyond this point there was no longer any effect. Moreover, in comparison with the infants who received placebo, the rHuEPO-treated infants had a better daily percent weight gain for a protein intake up to 3.5 gm/kg per day (p = 0.016). CONCLUSIONS: In VLBW infants treated with rHuEPO, higher protein intake up to 3.1 to 3.5 gm/kg per day improved the erythropoietic response, and protein utilization for growth was improved. During treatment with rHuEPO, infants who receive adequate protein to achieve satisfactory growth also receive sufficient protein for erythropoiesis.
M S Brown; H Shapiro
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  128     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-06-07     Completed Date:  1996-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  512-7     Citation Subset:  AIM; IM    
Department of Pediatrics, Presbyterian/St. Luke's Medical Center, Denver, Colorado, USA.
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MeSH Terms
Anemia, Neonatal / drug therapy*
Dietary Proteins / administration & dosage*
Double-Blind Method
Erythropoietin / therapeutic use*
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / drug therapy*
Infant, Very Low Birth Weight
Recombinant Proteins / therapeutic use
Reg. No./Substance:
0/Dietary Proteins; 0/Recombinant Proteins; 11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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