Document Detail

Effect of prostatic biopsy on free-to-total prostate-specific antigen ratio in patients with prostate cancer.
MedLine Citation:
PMID:  10710247     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We determined the effect of prostatic biopsy on the changes in total and free prostate-specific antigen (PSA) and free-to-total PSA ratio (F/T ratio) and examined if there are differences in these parameters between patients with benign and malignant histologic findings. METHODS: The concentration of total and free PSA and the F/T ratio were determined in 35 men before and 1 h after prostatic biopsy. The level of PSA was measured with a chemiluminescent enzyme assay. Of 35 patients, nine were diagnosed as having prostate cancer. RESULTS: In patients whose biopsy revealed cancer, the F/T ratio was lower than those without cancer, although there were no differences in total and free PSA value before prostatic biopsy. One hour after prostatic biopsy, there was an increase in the level of total and free PSA and the F/T ratio in all men. The increase in the F/T ratio was greater in patients whose biopsies revealed no prostate cancer. In patients with stage B cancer, these parameters increased more than those with stage C/D cancer. CONCLUSION: Prostatic biopsy causes a dramatic increase in total and free PSA. The F/T ratio also increased after biopsy. The PSA response to prostatic biopsy might be different in patients with and without prostatic malignancy. The response might also be different according to stage of prostate cancer.
Y Furuya; K Akakura; T Ichikawa; M Masai; T Igarashi; H Ito
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of urology : official journal of the Japanese Urological Association     Volume:  7     ISSN:  0919-8172     ISO Abbreviation:  Int. J. Urol.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-04-03     Completed Date:  2000-04-03     Revised Date:  2006-10-30    
Medline Journal Info:
Nlm Unique ID:  9440237     Medline TA:  Int J Urol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  49-53     Citation Subset:  IM    
Department of Urology, Teikyo University School of Medicine, Ichihara Hospital, Chiba, Japan.
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MeSH Terms
Aged, 80 and over
Middle Aged
Prostate-Specific Antigen / blood*
Prostatic Neoplasms / blood*,  pathology*
Time Factors
Reg. No./Substance:
EC Antigen

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