Document Detail

Effect of prostaglandins on pancreatic circulation in anesthetized dogs.
MedLine Citation:
PMID:  7050343     Owner:  NLM     Status:  MEDLINE    
To assess the contribution of prostaglandins (PGs) to the maintenance of vascular tone and exocrine secretion in the pancreas, the effects of several products of arachidonic acid metabolism on the blood flow and flow rate of exocrine secretion were examined in the isolated blood perfused pancreas of the pentobarbital-anesthetized dog with and without pretreatment with the cyclooxygenase inhibitors, indomethacin (2 mg/kg i.v.) or sodium meclofenamate (10 mg/kg i.v.). Intra-arterial administration of PGE2, PGI2 and thromboxane B2 at doses of 30 to 300 ng/kg produced vasodilation and increased flow of blood to the pancreas. Injections of either PGF2 alpha, 30 to 300 ng/kg, or PGD2, 10 to 100 ng/kg, produced a biphasic effect, viz., transient vasoconstriction followed by a prolonged vasodilation. Administration of either indomethacin or sodium meclofenamate significantly reduced pancreatic blood flow (P less than .01). In animals pretreated with either of the cyclooxygenase inhibitors, the effect of PGE2, PGI2 or PGD2 to increase blood flow to the pancreas was prolonged in duration. Administration of either PGs, thromboxane B2 or cyclooxygenase inhibitors did not markedly alter the flow rate of exocrine pancreatic secretion. These data indicate that one or more products of arachidonic acid formed through the cyclooxygenase pathway contribute to the maintenance of pancreatic vascular bed in a dilated state.
T Homma; K U Malik
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pharmacology and experimental therapeutics     Volume:  222     ISSN:  0022-3565     ISO Abbreviation:  J. Pharmacol. Exp. Ther.     Publication Date:  1982 Sep 
Date Detail:
Created Date:  1982-10-29     Completed Date:  1982-10-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376362     Medline TA:  J Pharmacol Exp Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  623-8     Citation Subset:  IM    
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MeSH Terms
Epoprostenol / pharmacology
Indomethacin / pharmacology
Meclofenamic Acid / pharmacology
Pancreas / blood supply*
Prostaglandins / pharmacology*
Prostaglandins D / pharmacology
Prostaglandins E / pharmacology
Regional Blood Flow / drug effects
Thromboxane B2 / pharmacology
Vasodilation / drug effects
Grant Support
Reg. No./Substance:
0/Prostaglandins; 0/Prostaglandins D; 0/Prostaglandins E; 35121-78-9/Epoprostenol; 363-24-6/Dinoprostone; 53-86-1/Indomethacin; 54397-85-2/Thromboxane B2; 644-62-2/Meclofenamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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