| Effect of prostaglandins on pancreatic circulation in anesthetized dogs. | |
| | |
MedLine Citation:
|
PMID: 7050343 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To assess the contribution of prostaglandins (PGs) to the maintenance of vascular tone and exocrine secretion in the pancreas, the effects of several products of arachidonic acid metabolism on the blood flow and flow rate of exocrine secretion were examined in the isolated blood perfused pancreas of the pentobarbital-anesthetized dog with and without pretreatment with the cyclooxygenase inhibitors, indomethacin (2 mg/kg i.v.) or sodium meclofenamate (10 mg/kg i.v.). Intra-arterial administration of PGE2, PGI2 and thromboxane B2 at doses of 30 to 300 ng/kg produced vasodilation and increased flow of blood to the pancreas. Injections of either PGF2 alpha, 30 to 300 ng/kg, or PGD2, 10 to 100 ng/kg, produced a biphasic effect, viz., transient vasoconstriction followed by a prolonged vasodilation. Administration of either indomethacin or sodium meclofenamate significantly reduced pancreatic blood flow (P less than .01). In animals pretreated with either of the cyclooxygenase inhibitors, the effect of PGE2, PGI2 or PGD2 to increase blood flow to the pancreas was prolonged in duration. Administration of either PGs, thromboxane B2 or cyclooxygenase inhibitors did not markedly alter the flow rate of exocrine pancreatic secretion. These data indicate that one or more products of arachidonic acid formed through the cyclooxygenase pathway contribute to the maintenance of pancreatic vascular bed in a dilated state. |
| | |
Authors:
|
T Homma; K U Malik |
Related Documents
:
|
6710353 - The role of lymphovenous communication in the development of postmastectomy lymphedema. 1553373 - Dissociation between the blood flow response of transplanted pancreatic islets and that... 14766033 - Serological surveillance of measles in blood donors in rio de janeiro, brazil. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Journal of pharmacology and experimental therapeutics Volume: 222 ISSN: 0022-3565 ISO Abbreviation: J. Pharmacol. Exp. Ther. Publication Date: 1982 Sep |
Date Detail:
|
Created Date: 1982-10-29 Completed Date: 1982-10-29 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0376362 Medline TA: J Pharmacol Exp Ther Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 623-8 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Dinoprostone Dogs Epoprostenol / pharmacology Indomethacin / pharmacology Male Meclofenamic Acid / pharmacology Pancreas / blood supply* Prostaglandins / pharmacology* Prostaglandins D / pharmacology Prostaglandins E / pharmacology Regional Blood Flow / drug effects Thromboxane B2 / pharmacology Vasodilation / drug effects |
| Grant Support | |
ID/Acronym/Agency:
|
HI19134/HI/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Prostaglandins; 0/Prostaglandins D; 0/Prostaglandins E; 35121-78-9/Epoprostenol; 363-24-6/Dinoprostone; 53-86-1/Indomethacin; 54397-85-2/Thromboxane B2; 644-62-2/Meclofenamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Stimulation of fibrinolytic activity in human skin fibroblasts by prostaglandins E1, E2 and I2.
Next Document: The effects of alanine, glucose and starch ingestion on the ketosis produced by exercise and by star...