Document Detail


Effect of prostaglandin synthesis inhibition on the central activity of noradrenaline in rats.
MedLine Citation:
PMID:  7246205     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of paracetamol and indomethacin on the action of centrally administered noradrenaline (NA) on the blood pressure, heart rate and rectal body temperature were studied in rats. It was demonstrated that both these substances increased NA effect on the arterial blood pressure and heart rate but caused no changes in NA effect on body temperature. These results suggest a modulating action of prostaglandins in the central nervous system on the functions of the centres regulating cardiovascular functions.
Authors:
R Brus; Z S Herman; A Sokoła; B Zielińska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta physiologica Polonica     Volume:  32     ISSN:  0044-6033     ISO Abbreviation:  Acta Physiol Pol     Publication Date:    1981 Jan-Feb
Date Detail:
Created Date:  1981-08-27     Completed Date:  1981-08-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985166R     Medline TA:  Acta Physiol Pol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  47-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetaminophen / pharmacology
Animals
Autonomic Nervous System / physiology*
Blood Pressure
Body Temperature
Heart Rate
Hemodynamics*
Indomethacin / pharmacology
Male
Norepinephrine / pharmacology,  physiology*
Prostaglandin Antagonists / pharmacology
Prostaglandins / physiology*
Rats
Chemical
Reg. No./Substance:
0/Prostaglandin Antagonists; 0/Prostaglandins; 103-90-2/Acetaminophen; 51-41-2/Norepinephrine; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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