Document Detail

Effect of prostaglandin inhibition on demeclocycline administration in conscious rats.
MedLine Citation:
PMID:  6774355     Owner:  NLM     Status:  MEDLINE    
Studies were performed in conscious rats to evaluate the role of renal prostaglandin biosynthesis in demeclocycline-induced polyuria. Three groups of animals were evaluated. Group 1 animals received only the diluents used for both demeclocycline and indomethacin. Group 2 received demeclocycline (20 mg/kg/day) and the indomethacin diluent. Group 3 received both demeclocycline and indomethacin (10 mg/kg/day). After eight days of demeclocycline administration, urine flow rate increased in the group 2 animals from 15.1 +/- 2.1 to 31.1 +/- 5.1 ml/day. Indomethacin failed to alter the magnitude of demeclocycline-induced polyuria despite a 60% reduction in urine prostaglandin E excretion rats. These studies demonstrate that the concentrating defect induced by demeclocycline can occur independent of alterations in praostaglandin biosynthesis and suggest that a change in renal prostaglandin biosynthesis is not an etiologic factor in demeclocycline-induced polyuria.
E R Serros; A G Lowe; M A Kirschenbaum
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Prostaglandins and medicine     Volume:  5     ISSN:  0161-4630     ISO Abbreviation:  Prostaglandins Med     Publication Date:  1980 Sep 
Date Detail:
Created Date:  1980-11-25     Completed Date:  1980-11-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7810330     Medline TA:  Prostaglandins Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  175-82     Citation Subset:  IM    
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MeSH Terms
Body Weight
Demeclocycline / pharmacology*
Glomerular Filtration Rate
Indomethacin / pharmacology
Polyuria / chemically induced
Prostaglandin Antagonists / pharmacology
Prostaglandins E / urine
Reg. No./Substance:
0/Prostaglandin Antagonists; 0/Prostaglandins E; 127-33-3/Demeclocycline; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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