Document Detail

Effect of prostaglandin I2 analogues on left ventricular diastolic function in vivo.
MedLine Citation:
PMID:  15993879     Owner:  NLM     Status:  MEDLINE    
The prostaglandin I2 analogues epoprostenol and iloprost increase left ventricular contractility. Therefore, we hypothesize that the prostaglandin I2 analogues epoprostenol and iloprost improve also left ventricular diastolic function. To test this hypothesis, the effects of epoprostenol and iloprost on left ventricular diastolic function were assessed in vivo and compared to two vasodilators sodium nitroprusside and adenosine, not formerly associated with changes of left ventricular contractility. Eleven pigs (25.9+/-2.8 kg, balanced anaesthesia) were exposed to the short-acting intravenous vasodilators sodium nitroprusside, adenosine and epoprostenol in a randomized cross over design. The long-acting iloprost was administered at the end of the protocol. The drugs are titrated to achieve a 25% reduction of diastolic aortic pressure. Active isovolumic relaxation properties of the left ventricle were assessed by the maximum velocity of left ventricular pressure drop. Passive phase of relaxation and filling was assessed by the determination of end diastolic compliance during a preload reduction manoeuvre. The maximum velocity of left ventricular pressure drop worsened during the infusion of sodium nitroprusside (baseline: -1950; sodium nitroprusside: -1293 mm Hg/s, p<0.05, Wilcoxon signed rank test versus vs. baseline) and adenosine (baseline: -2015; adenosine: -1345 mm Hg/s, p<0.05), but remained stable during the infusion of the prostaglandins (baseline: -1943; epoprostenol: -1785 mm Hg/s; baseline: -2042; iloprost: -1923 mm Hg/s). End diastolic compliance was not altered significantly by any vasodilator. Interstitial myocardial cAMP increased during the infusion of epoprostenol (7.60 to 13.87 fmol/ml, p<0.05) and tended to increase during the infusion of iloprost (7.56 to 11.66 fmol/ml, p=0.21). The prostaglandin I(2) analogues epoprostenol and iloprost preserved the early phase of active isovolumic relaxation, presumably mediated by myocardial cAMP, whereas sodium nitroprusside and adenosine impaired early active isovolumic relaxation. Passive relaxation and filling properties remained stable during the infusion of each applied vasodilator in the intact left ventricle in vivo.
Hille Kisch-Wedel; Gregor Kemming; Franz Meisner; Michael Flondor; Sebastian Bruhn; Carolina Koehler; Konrad Messmer; Bernhard Zwissler
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  517     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-12     Completed Date:  2005-09-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  208-16     Citation Subset:  IM    
Clinic of Anesthesiology, Ludwig Maximilian University, Marchioninistr. 15, D-81377 Munich, Germany.
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MeSH Terms
Adenosine / administration & dosage,  pharmacology
Antihypertensive Agents / administration & dosage,  pharmacology
Blood Pressure / drug effects
Cyclic AMP / metabolism
Epoprostenol / administration & dosage,  pharmacology*
Heart Rate / drug effects
Heart Ventricles / drug effects,  metabolism
Iloprost / administration & dosage,  pharmacology*
Infusions, Intravenous
Nitroprusside / administration & dosage,  pharmacology
Random Allocation
Time Factors
Vasodilator Agents / administration & dosage,  pharmacology
Ventricular Function
Ventricular Function, Left / drug effects*,  physiology
Reg. No./Substance:
0/Antihypertensive Agents; 0/Vasodilator Agents; 15078-28-1/Nitroprusside; 35121-78-9/Epoprostenol; 58-61-7/Adenosine; 60-92-4/Cyclic AMP; 78919-13-8/Iloprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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