| Effect of prostacyclin analogue iloprost on haemodynamic parameters during femoro-crural reconstruction. | |
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MedLine Citation:
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PMID: 1378685 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A randomised placebo-controlled trial was conducted to investigate the effects of iloprost, a stable prostacyclin analogue, on peripheral resistance, graft blood flow and mean systemic arterial blood pressure (MABP) during femoro-crural arterial bypass. 3000ng of iloprost, infused into the graft, produced an immediate drop in peripheral resistance by a mean (range) of 40% (4-80%) (P less than 0.01, Wilcoxon). Decreased peripheral resistance persisted to 20 minutes. Graft flow during the same period increased by 52% (-7 to 294%) (P less than 0.01). A transient maximal drop in mean MABP of 22% from 83-65 mmHg occurred 5 minutes post iloprost infusion but caused no detrimental effects and recovered to baseline values by 10 mins. Iloprost produces an immediate decrease in peripheral resistance associated with a prolonged increase in graft blood flow. This may reduce graft failure in the early postoperative period. |
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Authors:
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F C Smith; C P Shearman |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Agents and actions. Supplements Volume: 37 ISSN: 0379-0363 ISO Abbreviation: Agents Actions Suppl. Publication Date: 1992 |
Date Detail:
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Created Date: 1992-08-20 Completed Date: 1992-08-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7801014 Medline TA: Agents Actions Suppl Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 251-7 Citation Subset: IM |
Affiliation:
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University Department of Vascular Surgery, Queen Elizabeth Hospital, Birmingham, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Female Hemodynamics / drug effects* Humans Iloprost / pharmacology* Ischemia / surgery* Leg / blood supply*, surgery Male Middle Aged Regional Blood Flow / drug effects, physiology Transplantation, Autologous Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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78919-13-8/Iloprost |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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