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Effect of propranolol on the treatment of infantile hemangiomas: a single tertiary center 3-year experience.
MedLine Citation:
PMID:  23273264     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Background: Propranolol has recently become a successful first-line therapy in the treatment of infantile hemangiomas(IHs). Objective: To evaluate and analyze our experience of propranolol treatment for IHs. Methods: A retrospective, observational study was conducted. Medical records were reviewed. To evaluate the outcome of treatment, serial digital photographs using a visual analogue scale were compared. Results: Eighty-three patients with a mean age of 5.35±5.15 months had 107 IHs treated by oral propranolol at a dose of 2mg/kg/day. The mean percent improvement in the size and extent were 14.3% at 1week, 45.4% at 9weeks, 69.1% at 21weeks, and 83.8% at 53weeks after beginning propranolol treatment. Eight patients (9.6%) reported mild side effects including hypoglycemia(n=4), hypotension without associated symptoms(n=2), bradycardia(n=1) and somnolence(n =1). Regrowth of IH after cessation of propranolol was reported in 18patients (21.7%). There is no significant predictor of response to treatment and regrowth after cessation of treatment. Conclusions: Propranolol was highly effective and safe in the treatment of IHs. Effect of propranolol treatment started rapidly within 1 week, and was very promising regardless of patients' and lesions' characteristics. Based on our observation, we suggest that treatment should be continued several months after the proliferative phase is considered to stop clinically.
Authors:
Young Woon Park; Kkot Bora Yeom; Jae Woo Choi; Dong Young Kim; Hyoseung Shin; Kyu Han Kim
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-31
Journal Detail:
Title:  The Journal of dermatological treatment     Volume:  -     ISSN:  1471-1753     ISO Abbreviation:  J Dermatolog Treat     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8918133     Medline TA:  J Dermatolog Treat     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Seoul National University Hospital, Dermatology, Seoul , Korea, Republic of.
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