|Effect of propranolol on sympathetically mediated leg vasoconstriction in humans.|
|PMID: 17627989 Owner: NLM Status: MEDLINE|
|Sympatho-excitatory manoeuvres are used to study vascular responsiveness in humans, but it is unclear if circulating adrenaline attenuates peripheral vasoconstriction during these manoeuvres. We hypothesized that vasoconstrictor responses to three manoeuvres (neck pressure, unilateral thigh-cuff release and isometric handgrip) would be greater after the administration of the beta-adrenergic blocker propranolol. Seven men and six women underwent these manoeuvres while beat-by-beat arterial pressure (finger photoplethysmography), femoral mean blood velocity (Doppler ultrasound) and femoral artery diameter (edge-detection software) were measured. Femoral vascular conductance was calculated as flow/pressure. Propranolol had no effect on baseline femoral vascular conductance (P > 0.05). As a result of neck pressure, femoral vascular conductance was reduced 23.9 +/- 3.5% before vs. 33.2 +/- 3.2% after infusion of propranolol (P = 0.033). After thigh-cuff release, femoral vascular conductance declined 50.2 +/- 5.8% before vs. 57.4 +/- 9.6% after propranolol infusion (P = 0.496). During handgrip, femoral vascular conductance was reduced 47.2 +/- 9.6% before vs. 55.2 +/- 9.2% after propranolol administration (P = 0.447). After handgrip, women had a greater rise in conductance than men (women: 153 +/- 16.2%; men: 36.4 +/- 10.6%; P < 0.001), which was blunted by 54.8% by propranolol (P < 0.001 vs. control), but unaffected by propranolol in men (P = 0.355 vs. control). The finding that beta-adrenergic receptor-mediated vasodilatation minimally affects vascular responses to these sympatho-excitatory manoeuvres reinforces their utility in the investigation of sympathetic vascular regulation in humans. Interestingly, post-handgrip hyperaemia is greater in women than men and is, in part, beta-adrenergic receptor mediated.|
|Thomas K Pellinger; John R Halliwill|
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|Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-07-12|
|Title: The Journal of physiology Volume: 583 ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 2007 Sep|
|Created Date: 2007-09-03 Completed Date: 2007-11-20 Revised Date: 2013-06-06|
Medline Journal Info:
|Nlm Unique ID: 0266262 Medline TA: J Physiol Country: England|
|Languages: eng Pagination: 797-809 Citation Subset: IM|
|Department of Human Physiology, University of Oregon, Eugene, OR 97403-1240, USA.|
|APA/MLA Format Download EndNote Download BibTex|
administration & dosage,
Blood Flow Velocity / drug effects
Blood Pressure / drug effects
Epinephrine / blood
Femoral Artery / innervation*
Heart Rate / drug effects
Hyperemia / metabolism, physiopathology
Leg / blood supply*
Norepinephrine / blood
Propranolol / administration & dosage, pharmacology*
Receptors, Adrenergic, beta / drug effects*, metabolism
Sympathetic Nervous System / drug effects*, metabolism
Vasoconstriction / drug effects*
Vasodilator Agents / administration & dosage, pharmacology*
|HL-65305/HL/NHLBI NIH HHS|
|0/Adrenergic beta-Antagonists; 0/Receptors, Adrenergic, beta; 0/Vasodilator Agents; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 525-66-6/Propranolol|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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