Document Detail

Effect of propranolol on sympathetically mediated leg vasoconstriction in humans.
MedLine Citation:
PMID:  17627989     Owner:  NLM     Status:  MEDLINE    
Sympatho-excitatory manoeuvres are used to study vascular responsiveness in humans, but it is unclear if circulating adrenaline attenuates peripheral vasoconstriction during these manoeuvres. We hypothesized that vasoconstrictor responses to three manoeuvres (neck pressure, unilateral thigh-cuff release and isometric handgrip) would be greater after the administration of the beta-adrenergic blocker propranolol. Seven men and six women underwent these manoeuvres while beat-by-beat arterial pressure (finger photoplethysmography), femoral mean blood velocity (Doppler ultrasound) and femoral artery diameter (edge-detection software) were measured. Femoral vascular conductance was calculated as flow/pressure. Propranolol had no effect on baseline femoral vascular conductance (P > 0.05). As a result of neck pressure, femoral vascular conductance was reduced 23.9 +/- 3.5% before vs. 33.2 +/- 3.2% after infusion of propranolol (P = 0.033). After thigh-cuff release, femoral vascular conductance declined 50.2 +/- 5.8% before vs. 57.4 +/- 9.6% after propranolol infusion (P = 0.496). During handgrip, femoral vascular conductance was reduced 47.2 +/- 9.6% before vs. 55.2 +/- 9.2% after propranolol administration (P = 0.447). After handgrip, women had a greater rise in conductance than men (women: 153 +/- 16.2%; men: 36.4 +/- 10.6%; P < 0.001), which was blunted by 54.8% by propranolol (P < 0.001 vs. control), but unaffected by propranolol in men (P = 0.355 vs. control). The finding that beta-adrenergic receptor-mediated vasodilatation minimally affects vascular responses to these sympatho-excitatory manoeuvres reinforces their utility in the investigation of sympathetic vascular regulation in humans. Interestingly, post-handgrip hyperaemia is greater in women than men and is, in part, beta-adrenergic receptor mediated.
Thomas K Pellinger; John R Halliwill
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-07-12
Journal Detail:
Title:  The Journal of physiology     Volume:  583     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-03     Completed Date:  2007-11-20     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  797-809     Citation Subset:  IM    
Department of Human Physiology, University of Oregon, Eugene, OR 97403-1240, USA.
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MeSH Terms
Adrenergic beta-Antagonists / administration & dosage,  pharmacology*
Blood Flow Velocity / drug effects
Blood Pressure / drug effects
Epinephrine / blood
Femoral Artery / innervation*
Hand Strength
Heart Rate / drug effects
Hyperemia / metabolism,  physiopathology
Infusions, Intravenous
Laser-Doppler Flowmetry
Leg / blood supply*
Norepinephrine / blood
Propranolol / administration & dosage,  pharmacology*
Receptors, Adrenergic, beta / drug effects*,  metabolism
Sympathetic Nervous System / drug effects*,  metabolism
Time Factors
Vasoconstriction / drug effects*
Vasodilator Agents / administration & dosage,  pharmacology*
Grant Support
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Receptors, Adrenergic, beta; 0/Vasodilator Agents; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 525-66-6/Propranolol

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