Document Detail

Effect of propranolol and nitroglycerin on hemoglobin--oxygen affinity.
MedLine Citation:
PMID:  816659     Owner:  NLM     Status:  MEDLINE    
The effect of propranolol on the oxyhemoglobin dissociation curve (P-50) of coronary venous blood was studied in isolated canine hearts. I.v. administration of propranolol (0.5, 5.0 mg/kg) produced no significant change in P-50 over 4 hr. Following propranolol, an intracoronary infusion of nitroglycerin (10 mug/min) increased P-50. Addition of propranolol (5 X 10(-5) M to 1 X 10(-4)M) to central venous blood in vitro produced a significant increase in P-50. These data indicate that propranolol increases P-50 in vitro but does not increase P-50 in vivo, whereas nitroglycerin increases P-50 In vivo but not in vitro.
G J Gross; D C Warltier; H F Hardman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European journal of pharmacology     Volume:  36     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1976 Mar 
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  267-71     Citation Subset:  IM    
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MeSH Terms
Blood Gas Analysis
Coronary Vessels
Hemodynamics / drug effects
Hemoglobins / metabolism*
Myocardium / metabolism
Nitroglycerin / pharmacology*
Oxygen / blood*
Oxygen Consumption
Propranolol / pharmacology*
Reg. No./Substance:
0/Hemoglobins; 0/Oxyhemoglobins; 525-66-6/Propranolol; 55-63-0/Nitroglycerin; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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