Document Detail

Effect of propranolol on the acid base balance and hemodynamics of 'chronically instrumented' pregnant sheep.
MedLine Citation:
PMID:  6861606     Owner:  NLM     Status:  MEDLINE    
Maternal and fetal responses to i.v. admission of propranolol (4 mg/4 min) were investigated in 10 'steady-state' sheep experiments performed on 5 ewes and their fetuses at 101-128 days of gestation. Observations were made at 0, 5, 15, 30, 45, 60, 75, 90 and 120 min from the start of infusion. Transient decrease in fetal heart rate (p less than 0.05) was observed at 15 min, accompanied by fetal acidosis, which persisted throughout the experiment. Mean fetal pCO2 increased significantly at 5, 15 (p less than 0.025) and 75 min (p less than 0.05). Fetal pO2 decreased at 15 min (p less than 0.025). Oxygen saturation (O2%) decreased at 15 (p less than 0.001) and 60 min (p less than 0.025). Concomitant decreases in O2 content were noted at 15 (p less than 0.005), 30 (p less than 0.05), 60 (p less than 0.025) and 90 min (p less than 0.05). Mean fetal base excess decreased at 30 min (p less than 0.05). Mean maternal heart rate decreased at 15 (p less than 0.010) and 30 min (p less than 0.005), followed by an increase at 75 (p less than 0.05) and 90 min (p less than 0.05). Mean uterine blood flow remained unchanged during infusion and up to 90 min. However, it increased at 105 (p less than 0.025) and 120 min (p less than 0.05). It is suggested that propranolol causes definite fetal adverse effects and its usage during pregnancy must be limited to absolutely indicated situations.
J Ayromlooi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Developmental pharmacology and therapeutics     Volume:  6     ISSN:  0379-8305     ISO Abbreviation:  Dev Pharmacol Ther     Publication Date:  1983  
Date Detail:
Created Date:  1983-08-11     Completed Date:  1983-08-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8003947     Medline TA:  Dev Pharmacol Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  207-16     Citation Subset:  IM    
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MeSH Terms
Acid-Base Equilibrium / drug effects*
Fetus / drug effects*
Hemodynamics / drug effects*
Maternal-Fetal Exchange
Propranolol / adverse effects*
Uterus / drug effects
Reg. No./Substance:

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