Document Detail

Effect of propofol and clonidine on cerebral blood flow velocity and carbon dioxide reactivity in the middle cerebral artery.
MedLine Citation:
PMID:  14676561     Owner:  NLM     Status:  MEDLINE    
This study was designed to evaluate the effects of propofol alone and propofol-clonidine combination on human middle cerebral artery blood flow velocity (Vmca) and cerebrovascular carbon dioxide (CO2) response by using transcranial Doppler ultrasonography. Mean Vmca in response to changes in arterial partial pressure of CO2 (Paco2) was determined under the following conditions: awake (group 1), propofol anesthesia (group 2), and combined propofol-clonidine anesthesia (group 3). Normocapnic, hypercapnic, and hypocapnic values of heart rate, mean arterial pressure, partial end-tidal CO2 pressure, Paco2, and Vmca were obtained. The mean Vmca in groups 2 and 3 was significantly lower than that in group 1 at each level of Paco2. The calculated Vmca at each level of Paco2 was not different between groups 2 and 3. There was a correlation between Paco2 and Vmca in all groups, but in the anesthetized groups the effect of Paco2 on Vmca was attenuated. The present data demonstrated that clonidine-propofol does not change CO2 reactivity compared with propofol alone, but both anesthetics attenuate cerebral blood flow compared with awake controls.
Hasan Mirzai; Idil Tekin; Serdar Tarhan; Gulay Ok; Cihan Goktan
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of neurosurgical anesthesiology     Volume:  16     ISSN:  0898-4921     ISO Abbreviation:  J Neurosurg Anesthesiol     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-16     Completed Date:  2004-04-02     Revised Date:  2006-09-18    
Medline Journal Info:
Nlm Unique ID:  8910749     Medline TA:  J Neurosurg Anesthesiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM    
Department of Neurosurgery, Medical Faculty, Celal Bayar University, Manisa, Turkey.
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MeSH Terms
Adrenergic alpha-Agonists / pharmacology
Analysis of Variance
Anesthetics, Combined / pharmacology
Anesthetics, Intravenous / pharmacology
Blood Flow Velocity / drug effects,  physiology
Blood Pressure / drug effects,  physiology
Carbon Dioxide / blood,  physiology*
Cerebrovascular Circulation / drug effects*,  physiology
Clonidine / pharmacology*
Heart Rate / drug effects,  physiology
Middle Cerebral Artery / drug effects*,  ultrasonography
Partial Pressure
Propofol / pharmacology*
Ultrasonography, Doppler, Transcranial
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Anesthetics, Combined; 0/Anesthetics, Intravenous; 124-38-9/Carbon Dioxide; 2078-54-8/Propofol; 4205-90-7/Clonidine

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