Document Detail


Effect of propionylcarnitine on changes in endothelial function and plasma levels of adhesion molecules induced by acute exercise in patients with intermittent claudication.
MedLine Citation:
PMID:  16518521     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In patients with intermittent claudication, treadmill exercise may cause acute deterioration of endothelial function and increase in plasma concentrations of adhesion molecules. The authors evaluated the efficacy of intravenously administered propionylcarnitine (PLC)in preventing these phenomena. Thirty-six claudicants with postexercise decrease in brachial artery flow-mediated dilation (FMD)were randomized to either placebo or PLC (600 mg as a single bolus followed by 1 mg/kg/min for 60 minutes).In the 18 patients randomized to placebo, FMD markedly decreased with exercise before (from 6.8 +/-0.4% to 4.0 +/-0.4%; p < 0.001) and after treatment (from 6.5 +/-0.4% to 4.4 +/-0.5%; p < 0.001). By contrast, in the PLC group, FMD significantly decreased with exercise before treatment (from 8.0 +/-0.7% to 4.4 +/-0.4%; p < 0.001), but not after active drug administration (from 7.1 +/-0.7% to 6.0 +/-0.6%; p = 0.067). The difference between treatments was not significant (p = 0.099; ANOVA). However, in the PLC group, the authors found that the greater the exercise-induced deterioration in endothelial function before treatment, the greater the capacity of PLC to prevent a postexercise decrease in FMD (r = -0.50, p = 0.034). Accordingly, they analyzed data in the 19 patients with a baseline exercise-induced decrease in FMD >or=45% (ie, the median FMD reduction in the entire group of 36 patients), and found that the exercise-induced FMD decrease was less after PLC than after placebo (p = 0.046, ANOVA). In the same subgroup, the exercise-induced increase in plasma concentrations of soluble vascular cell adhesion molecule-1 (sVCAM-1) was significantly higher before than after treatment in patients randomized to PLC (23.4 +/-5% vs 15.3 +/-7%, p = 0.007). In conclusion, in patients with intermittent claudication suffering from a greater endothelial derangement after treadmill, PLC administration provided a protective effect against deterioration of FMD and increase of sVCAM-1 induced by exercise.
Authors:
Antonio Silvestro; Vittorio Schiano; Roxana Bucur; Gregorio Brevetti; Francesco Scopacasa; Massimo Chiariello
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Angiology     Volume:  57     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:    2006 Mar-Apr
Date Detail:
Created Date:  2006-03-06     Completed Date:  2006-04-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  145-54     Citation Subset:  IM    
Affiliation:
Department of Clinical Medicine, University of Naples Federico II,' Naples, Italy. antoniosilvestro@libero.it
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / blood
Brachial Artery / drug effects,  physiopathology,  ultrasonography
Cardiotonic Agents / administration & dosage,  therapeutic use*
Carnitine / administration & dosage,  analogs & derivatives*,  therapeutic use
Endothelium, Vascular / drug effects,  physiopathology*
Enzyme-Linked Immunosorbent Assay
Exercise Test
Exercise Therapy / methods*
Female
Humans
Injections, Intravenous
Intercellular Adhesion Molecule-1 / blood*
Intermittent Claudication / blood,  physiopathology,  therapy*
Male
Middle Aged
Severity of Illness Index
Treatment Outcome
Vascular Cell Adhesion Molecule-1 / blood*
Vasodilation / drug effects,  physiology*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cardiotonic Agents; 0/Vascular Cell Adhesion Molecule-1; 126547-89-5/Intercellular Adhesion Molecule-1; 17298-37-2/propionylcarnitine; 541-15-1/Carnitine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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