Document Detail


Effect of prophylactically administered edaravone during antegrade cerebral perfusion in a canine model of old cerebral infarction.
MedLine Citation:
PMID:  17320569     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Reactive free radical species are thought to be involved in postoperative neurologic dysfunction after antegrade selective cerebral perfusion in brains with old infarction. We assessed the brain protective effect of prophylactically administered edaravone, a free radical scavenger, for antegrade selective cerebral perfusion in brains with or without old infarction in a canine model. METHODS: A canine model of old cerebral infarction was created by injecting cylindric silicone embolus into the middle cerebral artery. Animals showing obvious neurologic deficits and surviving 4 weeks or longer were included in the model. Deep hypothermia with antegrade selective cerebral perfusion was performed in both intact (non-edaravone, group A; edaravone-treated, group B) and infarcted animals (non-edaravone, group C; edaravone-treated, group D). Serum concentrations of malondialdehyde, hexanoyl-lysine, glutamate, and venous-arterial lactate difference were measured, and central conduction time and amplitude of somatosensory evoked potentials were assessed during the operation. RESULTS: Compared with the intact groups, serum concentrations of malondialdehyde and hexanoyl-lysine in group C significantly increased at the end of antegrade selective cerebral perfusion, whereas that of glutamate did so in the rewarming phase. Increases in all these biochemical parameters were suppressed in group D. In group C, the venous-arterial lactate difference was significantly greater in the rewarming phase at 28 degrees C compared with intact groups. A significant prolongation of postoperative central conduction time and decrease in neuronal activity were detected in group C, both of which recovered in group D. CONCLUSION: Prophylactic administration of edaravone exerted a significant protective effect against postoperative neurologic dysfunction after antegrade selective cerebral perfusion in a canine model with old cerebral infarction.
Authors:
Takayasu Suzuki; Teruhisa Kazui; Seiji Yamamoto; Naoki Washiyama; Kazuhiro Ohkura; Kentaro Ohishi; Abul Hasan Muhammad Bashar; Katsushi Yamashita; Hitoshi Terada; Kazuchika Suzuki; Satoshi Akuzawa; Michio Fujie
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  133     ISSN:  1097-685X     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-26     Completed Date:  2007-03-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  710-6     Citation Subset:  AIM; IM    
Affiliation:
First Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan. tac.sz@hama-med.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Antipyrine / analogs & derivatives*,  pharmacology
Blood Chemical Analysis
Cardiopulmonary Bypass / methods
Cerebral Infarction / drug therapy*,  surgery
Cerebrovascular Circulation / drug effects*,  physiology
Disease Models, Animal
Dogs
Dose-Response Relationship, Drug
Drug Administration Schedule
Evoked Potentials, Somatosensory
Female
Infusions, Intravenous
Preoperative Care / methods
Probability
Random Allocation
Reference Values
Reperfusion / methods*
Reperfusion Injury / prevention & control
Sensitivity and Specificity
Chemical
Reg. No./Substance:
60-80-0/Antipyrine; 89-25-8/phenylmethylpyrazolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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