Document Detail


Effect of propellant on the pharmacokinetics and pharmacodynamics of inhaled albuterol in asthmatic subjects.
MedLine Citation:
PMID:  12737684     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hydrofluoroalkane (HFA) propellants have largely replaced chlorofluorocarbon (CFC) propellants in metered dose inhalers (MDI). It is important to document the pharmacokinetics (PK) and pharmacodynamics (PD) of medications delivered using HFA propellants compared to CFC propellants. Six adult asthmatics with mild to moderate asthma were selected for the study. Each subject inhaled 180 microg of albuterol from an MDI with holding chamber. Venous blood was collected for measuring albuterol levels at intervals over 12 h, and spirometric measurements of airflow were measured over the same time period. Plasma samples were analyzed using a GC/MS assay developed in our laboratory. PK and PD parameters were calculated by nonlinear regression using WinNonlin. There were no statistically significant differences between PD parameters for HFA versus CFC propellants. The area under the plasma albuterol concentration versus time curve (AUC) was 72% greater for the HFA formulation, indicating a greater lung bioavailability (p = 0.015). This difference in bioavailability did not result in a statistically significant difference in FEV(1) values between the two propellants.
Authors:
Vijay Joguparthi; Philip Breen; Cesar Compadre; Xiang Zhou; Larry Gann; F Charles Hiller; Paula Anderson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine     Volume:  16     ISSN:  0894-2684     ISO Abbreviation:  J Aerosol Med     Publication Date:  2003  
Date Detail:
Created Date:  2003-05-09     Completed Date:  2003-05-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8809251     Medline TA:  J Aerosol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  47-53     Citation Subset:  T    
Affiliation:
Department of Pharmaceutical Sciences and Division of Pulmonary and Critical Care Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Agonists / administration & dosage*,  pharmacokinetics,  pharmacology
Aerosol Propellants*
Albuterol / administration & dosage*,  pharmacokinetics,  pharmacology
Area Under Curve
Asthma / drug therapy
Biological Availability
Humans
Metered Dose Inhalers*
Chemical
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Aerosol Propellants; 18559-94-9/Albuterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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