Document Detail


Effect of prone position without PEEP on oxygenation and complacency in an experimental model.
MedLine Citation:
PMID:  17627322     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To observe the effects of the prone position and the need for positive end-expiratory pressure (PEEP) to improve oxygenation. METHOD: Sixteen rats were anesthetized and ventilated at a tidal volume of 8 mL/kg, respiratory rate of 60 rpm and PEEP = 0 cmH(2)O (ZEEP), in the supine position for 30 minutes. Lung injury was then induced by means of intratracheal instillation of hydrochloric acid. Once the injury was established, rats were placed in the prone position for a further 30 minutes and randomized into two groups: in group 1 PEEP = 5 cmH(2)O was added; while group 2 was kept on ZEEP. Measurements of pulmonary mechanics, arterial blood gas analysis and mean arterial pressure were taken at the end of each phase. RESULTS: In group 1, oxygen partial pressure increased significantly from 98.7+/-26.5 to 173.9+/-58.4 mmHg between injury and prone phases; in group 2 it was unchanged, varying from 99.6+/-15.4 to 100.5+/-24.5 mmHg. Group 1 also exhibited significant improvement in complacency, from 0.20+/-0.01 to 0.23+/-0.02 mL/cmH(2)O, while, once more, group 2 did not exhibit improvement, going from 0.21+/-0.02 to 0.22+/-0.01 mL/cmH(2)O. Mean arterial blood pressure measurements did not change significantly in either group at any point during the experiment. CONCLUSIONS: The prone position only resulted in improved oxygenation and respiratory mechanics when combined with PEEP = 5 cmH(2)O. The prone position did not cause hemodynamic compromise with or without PEEP = 5 cmH(2)O.
Authors:
Ana Cristina Z Yagui; Oswaldo S Beppu
Publication Detail:
Type:  Journal Article     Date:  2007-07-12
Journal Detail:
Title:  Jornal de pediatria     Volume:  83     ISSN:  0021-7557     ISO Abbreviation:  J Pediatr (Rio J)     Publication Date:    2007 Jul-Aug
Date Detail:
Created Date:  2007-08-06     Completed Date:  2008-02-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985188R     Medline TA:  J Pediatr (Rio J)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  343-8     Citation Subset:  IM    
Affiliation:
Universidade Federal de São Paulo - Escola Paulista de Medicina (UNIFESP-EPM), São Paulo, SP, Brazil. anac.yagui@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Male
Oxygen / blood*
Positive-Pressure Respiration*
Prone Position*
Pulmonary Circulation
Pulmonary Gas Exchange
Pulmonary Ventilation / physiology*
Rats
Rats, Wistar
Respiratory Distress Syndrome, Adult / physiopathology*,  therapy
Total Lung Capacity / physiology*
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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