| Effect of prolonged interferon therapy on the outcome of hepatitis C virus-related cirrhosis: a randomized trial. | |
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MedLine Citation:
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PMID: 17261383 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND & AIMS: The impact of interferon (IFN) treatment on the occurrence of complications related to hepatitis C virus (HCV)-related cirrhosis is debated because the majority of studies are retrospective. We designed a randomized controlled trial comparing the efficacy of prolonged IFN alfa-2a treatment vs nontreatment on complication-free survival in patients with compensated HCV cirrhosis. METHODS: A total of 102 patients (mean age, 60.5 +/- 9.5 y; male/female ratio, .82) with biopsy examination-proven HCV cirrhosis, Child-Pugh score A, who were hepatocellular carcinoma (HCC) free, and had at least 1 risk factor of complications were randomized to receive IFN or no therapy for 24 months. RESULTS: During the follow-up evaluation, the complication rate was 24.5%: HCC occurred in 12 and decompensation unrelated to HCC occurred in 13 patients. The number of HCC patients was similar in both groups. The probability of complication-free survival was not significantly different between treated and untreated patients (98% and 72.3% vs 90% and 70.7% at 12 and 24 mo, respectively, P = .59). The median time until complication occurrence was 17.1 months in the treated group vs 13.6 months in the untreated group (P = .2). CONCLUSIONS: This randomized controlled trial showed that a 2-year course of IFN has little or no impact on complication-free survival in patients with high-risk compensated HCV cirrhosis. |
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Authors:
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Laetitia Fartoux; Françoise Degos; Christian Trépo; Odile Goria; Paul Calès; Albert Tran; Catherine Buffet; Thierry Poynard; Dominique Capron; Jean-Jacques Raabe; Dominique Roulot; Sylvie Naveau; Jean-Didier Grange; Renée E Poupon; Raoul Poupon; Lawrence Serfaty |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2007-01-29 |
Journal Detail:
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Title: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association Volume: 5 ISSN: 1542-7714 ISO Abbreviation: Clin. Gastroenterol. Hepatol. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-20 Completed Date: 2007-05-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101160775 Medline TA: Clin Gastroenterol Hepatol Country: United States |
Other Details:
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Languages: eng Pagination: 502-7 Citation Subset: IM |
Affiliation:
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AP-HP, Hôpital Saint-Antoine, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antiviral Agents / therapeutic use Confidence Intervals Disease-Free Survival Dose-Response Relationship, Drug Drug Administration Schedule Female Hepatitis C, Chronic / diagnosis, drug therapy, mortality* Humans Interferon Alfa-2a / therapeutic use* Liver Cirrhosis / drug therapy*, mortality*, virology* Male Middle Aged Odds Ratio Probability Prognosis Proportional Hazards Models Prospective Studies Reference Values Risk Assessment Severity of Illness Index Survival Analysis Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 76543-88-9/Interferon Alfa-2a |
| Comments/Corrections | |
Comment In:
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Clin Gastroenterol Hepatol. 2007 Apr;5(4):427-9
[PMID:
17445750
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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