Document Detail

Effect of prolonged cimetidine therapy on gastric acid secretion in man.
MedLine Citation:
PMID:  344157     Owner:  NLM     Status:  MEDLINE    
In a double blind trial, 23 patients with endoscopically confirmed duodenal ulceration received cimetidine (300 mg four times daily in six patients, or 400 mg four times daily in 10 patients) or placebo (seven patients) for six weeks. Before entry into the trial, pentagastrin (6 gastric acid secretion after a single oral dose of 300 or 400 mg cimetidine was lowered by 82.1% and 81.0%, respectively, while no significant inhibition was recorded in the patients receiving placebo (8.8%). The same test repeated after six weeks of continuous treatment showed that the effect of the drug was maintained, the percentage inhibition of acid secretion being of the same order as in the first test.
G O Barbezat; S Bank
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Gut     Volume:  19     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1978 Feb 
Date Detail:
Created Date:  1978-05-08     Completed Date:  1978-05-08     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  151-4     Citation Subset:  AIM; IM    
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MeSH Terms
Cimetidine / pharmacology*,  therapeutic use
Clinical Trials as Topic
Double-Blind Method
Duodenal Ulcer / drug therapy
Gastric Emptying / drug effects
Gastric Juice / secretion*
Guanidines / pharmacology*
Middle Aged
Pentagastrin / pharmacology
Reg. No./Substance:
0/Guanidines; 51481-61-9/Cimetidine; 5534-95-2/Pentagastrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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