| Effect of prolactin inhibitory agents on the ectopic anterior pituitary and the mammary gland in rats. | |
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MedLine Citation:
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PMID: 325978 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of the present study was to investigate the biological effectiveness of two highly potent prolactin (PRL) inhibitors, lisuride hydrogen maleate (LMH) and 2-Br-alpha-ergocryptine (CB-154), in the absence of hypothalamic factors acting directly at the level of the anterior pituitary. Hypophysectomized female rats bearing 4 transplanted pituitaries beneath the kidney capsules were treated with oestradiol benzoate (OeB) and progesterone (P) with or without simultaneous administration of LHM or CB-154 for 22 days in order stimulate or inhibit lobula-alveolar growth of the mammary glands. In addition to the investigation of the mammary glands by DNA determination and assessment of the histological pictures, the aim of this study was directed towards the influence of the substances tested at the level of the anterior pituitary remote from the hypothalmus. In this connection the changes in the different cells within the ectopic pituitaries as revealed by immunoenzyme-cytochemical studies were investigated. The results obtained support the classical view of a neuroendocrine regulation of mammary gland growth and the importance of oestrogens, P and PRL within this system. Both ergot derivatives LHM and CB-154 were able to antagonize the stimulatory effect of OeB combined with P on the mammary gland. With regard to the mechanism of action of LHM and CB-154 it is concluded that both substances act via a direct action on dopaminergic receptors within the ectopic anterior pituitary. |
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Authors:
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K J Gräf; R Horowski; M F Etreby |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta endocrinologica Volume: 85 ISSN: 0001-5598 ISO Abbreviation: Acta Endocrinol. Publication Date: 1977 Jun |
Date Detail:
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Created Date: 1977-07-18 Completed Date: 1977-07-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370312 Medline TA: Acta Endocrinol (Copenh) Country: DENMARK |
Other Details:
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Languages: eng Pagination: 267-78 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bromocriptine / pharmacology* DNA / metabolism Ergolines / pharmacology* Estradiol / pharmacology Female Histocytochemistry Hypophysectomy Immunoenzyme Techniques Maleates / pharmacology* Mammary Glands, Animal / drug effects*, metabolism Organ Size / drug effects Pituitary Gland / drug effects* Pituitary Gland, Anterior / drug effects*, metabolism, transplantation Progesterone / pharmacology Prolactin / antagonists & inhibitors*, metabolism Rats Transplantation, Autologous |
| Chemical | |
Reg. No./Substance:
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0/Ergolines; 0/Maleates; 25614-03-3/Bromocriptine; 50-28-2/Estradiol; 57-83-0/Progesterone; 9002-62-4/Prolactin; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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