Document Detail

Effect of prokinetic agents on ileal contractility in a rabbit model of gastroschisis.
MedLine Citation:
PMID:  9126764     Owner:  NLM     Status:  MEDLINE    
Intestinal hypomotility is a major problem after repair of gastroschisis. The authors assessed the effect of four clinically available prokinetic agents on intestinal contractility using a rabbit model of gastroschisis. Gastroschisis was surgically created at 24 days' gestation in fetal rabbits. At term, 10-mm ileal muscle strips were harvested, suspended in an organ bath, and stimulated with 10(-6) mol/L carbechol with and without each prokinetic agent: metoclopromide (1 x 10(-5) mol/L), cisapride (2 x 10(-5) mol/L), erythromycin (1 x 10(-5) mol/L), and octreotide (5 x 10(-5) mol/L). The effect of each agent on contractility was calculated as percent change from maximal response to carbechol alone. There were two control groups: sham operated fetuses, and maternal ileum. Metoclopromide was effective only in the adult rabbits. Cisapride improved contractility in newborns with gastroschisis, as well as in both newborn and adult control groups. Neither erythromycin or octreotide improved bethanechol-induced contractility in any of the animals. These data suggest that cisapride may be useful for treating hypoperistalsis in infants with gastroschisis. Clinical studies must be done to further pursue this finding.
J C Langer; G Bramlett
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  32     ISSN:  0022-3468     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-06-27     Completed Date:  1997-06-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  605-8     Citation Subset:  IM    
Department of Surgery, Washington University School of Medicine and St Louis Children's Hospital, MO 63110, USA.
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MeSH Terms
Abdominal Muscles / abnormalities*
Animals, Newborn
Bethanechol / pharmacology
Congenital Abnormalities / physiopathology
Erythromycin / pharmacology
Gastrointestinal Agents / pharmacology*
Gastrointestinal Motility / drug effects
Ileum / drug effects,  physiopathology*
Metoclopramide / pharmacology
Muscle Contraction / drug effects*
Octreotide / pharmacology
Piperidines / pharmacology
Reg. No./Substance:
0/Gastrointestinal Agents; 0/Piperidines; 114-07-8/Erythromycin; 364-62-5/Metoclopramide; 674-38-4/Bethanechol; 81098-60-4/Cisapride; 83150-76-9/Octreotide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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