Document Detail


Effect of proguanil and cycloguanil on human lymphocytes in vitro.
MedLine Citation:
PMID:  3874067     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The in vitro effect of proguanil and its active metabolite cycloguanil on proliferating human blood mononuclear cells was studied. Proguanil had no effect on 14C-thymidine incorporation or on the number of cells. Cycloguanil, in concentrations corresponding to the plasma levels found in clinical practice, blocked the endogenous synthesis of thymidine and decreased the number of mitogen- and antigen-stimulated cells. The effect on phytohaemagglutinin-stimulated cells was transient. Higher concentrations of cycloguanil, corresponding to intralymphocytic levels in clinical practice, permanently suppressed the growth of lymphocytes. The effect of cycloguanil could be reversed by low doses of folinic acid and high doses of folic acid.
Authors:
I C Bygbjerg
Related Documents :
3494727 - Accessory cell requirements in mitogen-induced rabbit t lymphocyte proliferation in an ...
6333567 - Functions of multinucleated giant cells formed by fusing rat alveolar macrophages with ...
22199267 - Characterization of t-cell memory phenotype after in vitro expansion of tumor-infiltrat...
22264637 - Live attenuated influenza virus (laiv) induces different mucosal t cell function in non...
15294967 - Early expression of a functional tcrbeta chain inhibits tcrgamma gene rearrangements wi...
18021737 - Analysis of cellular responses to mycoplasma mycoides subsp. mycoides small colony biot...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  28     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1985  
Date Detail:
Created Date:  1985-08-12     Completed Date:  1985-08-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  287-90     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Chloroguanide / pharmacology*
Humans
Leucovorin / pharmacology
Lymphocyte Activation / drug effects*
Thymidine / metabolism
Triazines / pharmacology*
Chemical
Reg. No./Substance:
0/Triazines; 50-89-5/Thymidine; 500-92-5/Chloroguanide; 516-21-2/cycloguanil; 58-05-9/Leucovorin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Percutaneous radio frequency gangliolysis in the treatment of trigeminal neuralgia.
Next Document:  Immune responses of thymus/lymphocyte embryonic chimeras: studies on tolerance and major histocompat...