Document Detail

Effect of proguanil and cycloguanil on human lymphocytes in vitro.
MedLine Citation:
PMID:  3874067     Owner:  NLM     Status:  MEDLINE    
The in vitro effect of proguanil and its active metabolite cycloguanil on proliferating human blood mononuclear cells was studied. Proguanil had no effect on 14C-thymidine incorporation or on the number of cells. Cycloguanil, in concentrations corresponding to the plasma levels found in clinical practice, blocked the endogenous synthesis of thymidine and decreased the number of mitogen- and antigen-stimulated cells. The effect on phytohaemagglutinin-stimulated cells was transient. Higher concentrations of cycloguanil, corresponding to intralymphocytic levels in clinical practice, permanently suppressed the growth of lymphocytes. The effect of cycloguanil could be reversed by low doses of folinic acid and high doses of folic acid.
I C Bygbjerg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  28     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1985  
Date Detail:
Created Date:  1985-08-12     Completed Date:  1985-08-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  287-90     Citation Subset:  IM    
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MeSH Terms
Chloroguanide / pharmacology*
Leucovorin / pharmacology
Lymphocyte Activation / drug effects*
Thymidine / metabolism
Triazines / pharmacology*
Reg. No./Substance:
0/Triazines; 50-89-5/Thymidine; 500-92-5/Chloroguanide; 516-21-2/cycloguanil; 58-05-9/Leucovorin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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