Document Detail

Effect of progesterone on peripheral blood flow in prepubertal female anesthetized pigs.
MedLine Citation:
PMID:  11740156     Owner:  NLM     Status:  MEDLINE    
This study was undertaken to determine the effects of progesterone on the peripheral circulation. In prepubertal female pigs anesthetized with sodium pentobarbitone, changes in the superior mesenteric, left renal and left external iliac flow caused by intravenous infusion of progesterone were assessed using electromagnetic flow meters. Changes in heart rate and arterial blood pressure were prevented by atrial pacing and by connecting the arterial system to a pressurized reservoir containing Ringer solution. In 20 pigs, infusion of 1 mg/kg of progesterone increased mesenteric, renal and iliac flow. In a further 4 pigs, the vasodilatory effects of the hormone were enhanced by graded increases in the dose between 1, 2 and 3 mg/kg. The mechanisms of these responses were studied in the 20 pigs by repeating the experiment after hemodynamic variables had returned to the control values before infusion. In 5 pigs, blockade of adrenergic receptors with propranolol and phentolamine did not affect the responses elicited by progesterone. The increases in mesenteric, renal and iliac flow to progesterone were prevented, respectively, by the injection of N(omega)-nitro-L-arginine methyl ester into the mesenteric (5 pigs), the renal (5 pigs) or the iliac artery (5 pigs). The present study shows that intravenous infusion of progesterone dilated mesenteric, renal and iliac circulations. The mechanism of this response involved the release of nitric oxide.
C Molinari; A Battaglia; E Grossini; D A Mary; N Surico; G Vacca
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of vascular research     Volume:  38     ISSN:  1018-1172     ISO Abbreviation:  J. Vasc. Res.     Publication Date:    2001 Nov-Dec
Date Detail:
Created Date:  2001-12-12     Completed Date:  2002-01-16     Revised Date:  2010-04-12    
Medline Journal Info:
Nlm Unique ID:  9206092     Medline TA:  J Vasc Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  569-77     Citation Subset:  IM    
Copyright Information:
Copyright 2001 S. Karger AG, Basel
Laboratorio di Fisiologia, Dipartimento di Scienze Mediche, Facolt? di Medicina e Chirurgia di Novara, Universit? del Piemonte Orientale A. Avogadro, Novara, Italy.
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MeSH Terms
Adrenergic alpha-Antagonists / pharmacology
Blood Circulation / drug effects*
Cardiovascular System / drug effects
Enzyme Inhibitors / pharmacology
Iliac Artery / physiology
Infusions, Intravenous
NG-Nitroarginine Methyl Ester / pharmacology
Phentolamine / pharmacology
Progesterone / administration & dosage,  pharmacology*
Propranolol / pharmacology
Regional Blood Flow / drug effects
Renal Circulation / drug effects
Splanchnic Circulation / drug effects
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Enzyme Inhibitors; 50-60-2/Phentolamine; 50903-99-6/NG-Nitroarginine Methyl Ester; 525-66-6/Propranolol; 57-83-0/Progesterone

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