Document Detail

Effect of progesterone alone and in combination with either corticosterone, 17 beta-estradiol or insulin on prolactin-stimulated fatty acid synthesis in mammary explants from pseudopregnant rabbits.
MedLine Citation:
PMID:  6391451     Owner:  NLM     Status:  MEDLINE    
Progesterone up to 15.9 mumol/l progressively suppressed prolactin-stimulated fatty acid synthesis in cultured mammary explants from 11-day pseudopregnant rabbits, but did not influence the proportion of fatty acids of medium chain length (C8:0-C12:0). Greater sensitivity to progesterone inhibition was observed at the low end of the ranges of corticosterone (29 nmol/l) and insulin (4.2 nmol/l) concentrations in the culture medium, which suggests an interaction between the hormones. A range of from 0.0001 to 10 mumol/l of 17 beta-estradiol concentrations had no effect on prolactin-stimulated fatty acid synthesis in the presence or absence of progesterone.
P Martyn; I R Falconer
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Australian journal of biological sciences     Volume:  37     ISSN:  0004-9417     ISO Abbreviation:  Aust. J. Biol. Sci.     Publication Date:  1984  
Date Detail:
Created Date:  1985-01-18     Completed Date:  1985-01-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370613     Medline TA:  Aust J Biol Sci     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  79-84     Citation Subset:  IM    
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MeSH Terms
Corticosterone / pharmacology*
Culture Techniques
Estradiol / pharmacology*
Fatty Acids / biosynthesis*
Insulin / pharmacology*
Lactates / metabolism
Lactic Acid
Mammary Glands, Animal / metabolism*
Progesterone / pharmacology*
Prolactin / pharmacology*
Pseudopregnancy / metabolism*
Reg. No./Substance:
0/Fatty Acids; 0/Lactates; 11061-68-0/Insulin; 50-21-5/Lactic Acid; 50-22-6/Corticosterone; 50-28-2/Estradiol; 57-83-0/Progesterone; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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