| Effect of probucol on vascular remodeling due to atherosclerosis in rabbits: an intravascular ultrasound study. | |
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MedLine Citation:
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PMID: 21740843 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Probucol is known to reduce the development of atherosclerotic lesions, but its impact on vascular remodeling associated with de novo atherosclerosis is incompletely understood. We therefore examined the effect of probucol on vascular remodeling in a rabbit model of established atherosclerosis. METHODS: Aortic atherosclerosis was induced by a combination of endothelial injury and 10 weeks' atherogenic diet. Animals were then randomized to receive the foregoing diet without or with 1% (wt/wt) probucol for 16 weeks. At the end of week 26, in vivo intravascular ultrasound, pathological, immunohistochemical and gene expression studies were performed. RESULTS: Probucol significantly decreased vessel cross-sectional area, plaque area and plaque burden without effect on lumen area. More negative remodeling and less positive remodeling occurred in the abdominal aortas of probucol group than the control group (56% vs. 21%, 18% vs. 54%, respectively, both P < 0.01). In addition, the probucol group showed a smaller mean remodeling index relative to the control group (0.93 ± 0.13 vs. 1.05 ± 0.16, P < 0.01). Furthermore, probucol treatment decreased macrophage infiltration, inhibited apoptosis of cells within plaques, and reduced the production of matrix metalloproteinases-2, -9, cathepsin K and cathepsin S (all P < 0.01). CONCLUSIONS: These findings suggest that probucol may attenuate the enlargement of atherosclerotic vessel walls and be associated with a negative remodeling pattern without affecting the lumen size. This effect may involve inhibition of extracellular matrix degradation and prevention of apoptosis in atherosclerotic plaques. |
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Authors:
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Ting-Ting Li; Yi Xie; Yuan Guo; Hong-Bo Tian; Jian-Ning Zhang; Jie Peng; Yun Zhang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chinese medical journal Volume: 124 ISSN: 0366-6999 ISO Abbreviation: Chin. Med. J. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-07-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7513795 Medline TA: Chin Med J (Engl) Country: China |
Other Details:
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Languages: eng Pagination: 1840-7 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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