Document Detail


Effect of probiotics on gastrointestinal function: evidence from animal models.
MedLine Citation:
PMID:  21180552     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The digestive tract works through a complex net of integrative functions. At the level of the gut, this integration occurs between the immune, neuromotor and endocrine systems, the intestinal barrier and gut luminal contents. Gastrointestinal function is controlled and coordinated by the central nervous system to ensure effective motility, secretion, absorption and mucosal immunity. Thus, it is clear that the gut keeps a tightly regulated equilibrium between luminal stimuli, epithelium, immunity and neurotransmission in order to maintain homeostasis. It follows that perturbations of any of these systems may lead to gut dysfunction. While we acknowledge that the gut-brain axis is crucial in determining coordinated gut function, in this review we will focus on peripheral mechanisms that influence gastrointestinal physiology and pathophysiology. We will discuss the general hypothesis that the intestinal content is crucial in determining what we consider normal gastrointestinal physiology, and consequently that alteration in luminal content by dietary, antibiotic or probiotic manipulation can result in changes in gut function. This article focuses on lessons learned from animal models of gut dysfunction.
Authors:
Elena F Verdú; Premysl Bercik; Stephen M Collins
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Therapeutic advances in gastroenterology     Volume:  2     ISSN:  1756-2848     ISO Abbreviation:  Therap Adv Gastroenterol     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2010-12-24     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101478893     Medline TA:  Therap Adv Gastroenterol     Country:  England    
Other Details:
Languages:  eng     Pagination:  31-5     Citation Subset:  -    
Affiliation:
Department of Medicine, McMaster University, Hamilton, Canada verdue@mcmaster.ca.
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