| Effect of probiotics L. acidophilus on C. rodentium colitis: the role of dendritic cells. | |
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MedLine Citation:
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PMID: 19047959 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Modulation of the intestinal immune response early in life by administration of probiotic bacteria may be an effective strategy for preventing or attenuating infectious diarrhea. We pre-inoculated the mice early in life with the probiotic bacteria L. acidophilus NCFM (La) at age 2 weeks. Dendritic cells (DCs) were collected and purified from mesenteric lymph nodes (MLN) and spleens of the BalbC/ByJ mice. DC isolation and adoptive transfer was used to examine the function of probiotics. We demonstrated that when mice were adoptively transferred with La-primed DCs instead of oral consumption with La there was a similar effect on fecal bacteria counts, IgA levels, and colonic histopathology, as well as cytokine levels in MLN when there was intestinal bacterial infection. The above findings suggest that DCs play a key role in probiotics attenuating C. rodentium (Cr) colitis. Moreover, the location of La-primed DC hints that there is interaction of dendritic cells and T cells in the digestive system of the host. Up-regulated expression of a surface marker on DCs indicated that inoculation with probiotics will stimulate the function of DCs, thereby further increasing immune response triggered by DC. |
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Authors:
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Chien-Chang Chen; Cheng-Hsun Chiu; Tzou-Yien Lin; Hai Ning Shi; W Allan Walker |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2008-9-17 |
Journal Detail:
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Title: Pediatric research Volume: - ISSN: 1530-0447 ISO Abbreviation: Pediatr. Res. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-12-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Pediatrics [C.-C.C, C.-H.C., T.-Y.L.], Chang Gung University College of Medicine, Taoyuan, 333, Taiwan; Mucosal Immunology Laboratory [H.N.S., W.A.W.], Harvard Medical School, Charlestown, MA 02129. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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