| Effect of probiotic mix (Bifidobacterium bifidum, Bifidobacterium lactis, Lactobacillus acidophilus) in the primary prevention of eczema: a double-blind, randomized, placebo-controlled trial. | |
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MedLine Citation:
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PMID: 19840300 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Controversy exists regarding the preventive effect of probiotics on the development of eczema or atopic dermatitis. We investigated whether supplementation of probiotics prevents the development of eczema in infants at high risk. In a randomized, double-blind, placebo-controlled trial, 112 pregnant women with a family history of allergic diseases received a once-daily supplement, either a mixture of Bifidobacterium bifidum BGN4, B. lactis AD011, and Lactobacillus acidophilus AD031, or placebo, starting at 4-8 wks before delivery and continuing until 6 months after delivery. Infants were exclusively breast-fed during the first 3 months, and were subsequently fed with breastmilk or cow's milk formula from 4 to 6 months of age. Clinical symptoms of the infants were monitored until 1 yr of age, when the total and specific IgE against common food allergens were measured. A total of 68 infants completed the study. The prevalence of eczema at 1 yr in the probiotic group was significantly lower than in the placebo group (18.2% vs. 40.0%, p=0.048). The cumulative incidence of eczema during the first 12 months was reduced significantly in probiotic group (36.4% vs. 62.9%, p=0.029); however, there was no difference in serum total IgE level or the sensitization against food allergens between the two groups. Prenatal and postnatal supplementation with a mixture of B. bifidum BGN4, B. lactis AD011, and L. acidophilus AD031 is an effective approach in preventing the development of eczema in infants at high risk of allergy during the first year of life. |
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Authors:
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Ji Yeun Kim; Jung Hyun Kwon; So Hyun Ahn; Sang Il Lee; Young Shin Han; Young Ok Choi; Soo Young Lee; Kang Mo Ahn; Geun Eog Ji |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2009-10-14 |
Journal Detail:
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Title: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology Volume: 21 ISSN: 1399-3038 ISO Abbreviation: Pediatr Allergy Immunol Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-05-06 Completed Date: 2010-08-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9106718 Medline TA: Pediatr Allergy Immunol Country: England |
Other Details:
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Languages: eng Pagination: e386-93 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 John Wiley & Sons A/S |
Affiliation:
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Department of Food and Nutrition, College of Human Ecology, Seoul National University, San 56-1, Shinlimdong, Kwanakku, Seoul, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bifidobacterium
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classification,
immunology* Breast Feeding Dermatitis, Atopic / epidemiology, immunology, prevention & control Double-Blind Method Eczema / epidemiology*, immunology, prevention & control Female Food Hypersensitivity / prevention & control Humans Immunoglobulin E / blood Incidence Infant Infant, Newborn Lactobacillus acidophilus / immunology* Postnatal Care Pregnancy Prenatal Care Prevalence Probiotics / administration & dosage* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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