Document Detail

Effect of prior oxygen exposure on the electroretinographic responses of infant rats.
MedLine Citation:
PMID:  7657546     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To study electroretinographic responses of infant rats with a history of exposure to high-ambient oxygen. METHODS: Electroretinographic responses to a range of full-field stimuli were recorded from 13-day-old (n = 8) and 18-day-old (n = 10) rats with a history of intermittent exposure to 80% oxygen and age-matched controls. The a-waves were fitted with a model of rod cell sensitivity and saturated response amplitude. The amplitudes and implicit times of the b-wave and oscillatory wavelets were examined as a function of stimulus energy. Response parameters in oxygen-exposed rats were compared to those in controls. RESULTS: The amplitude of the saturated rod response was reduced in oxygen-exposed 13-day-old but not 18-day-old rats. The sensitivity of the rod response was reduced in both 13- and 18-day-old oxygen-exposed rats. The saturated amplitude and sensitivity of the b-wave did not differ significantly between oxygen-exposed and control rats age 13 days, but both amplitude and sensitivity were significantly decreased in 18-day-old oxygen-exposed rats. Oscillatory potentials, which could be investigated only in 18-day-old rats, showed significant attenuation of OP3 but not OP4 amplitudes in the oxygen-exposed rats. The sensitivity of OP2 did not differ significantly between oxygen-exposed and control rats. The avascular area in the oxygen-exposed rats was not correlated with any of the rod cell, b-wave, or oscillatory potential response parameters. CONCLUSION: The function of the rod photoreceptors, as well as the inner retina, is altered in infant rats with a history of oxygen exposure.
X Reynaud; R M Hansen; A B Fulton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  36     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1995-10-02     Completed Date:  1995-10-02     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2071-9     Citation Subset:  IM    
Department of Ophthalmology, Childen's Hospitalk, Boston, MA 02115, USA.
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MeSH Terms
Animals, Newborn
Electroretinography / drug effects
Infant, Newborn
Neurons / drug effects,  physiology
Oxygen / toxicity*
Rats, Sprague-Dawley
Retina / drug effects,  physiology*
Retinal Rod Photoreceptor Cells / drug effects,  physiology
Retinopathy of Prematurity / etiology,  physiopathology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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