| Effect of prior oxygen exposure on the electroretinographic responses of infant rats. | |
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MedLine Citation:
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PMID: 7657546 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To study electroretinographic responses of infant rats with a history of exposure to high-ambient oxygen. METHODS: Electroretinographic responses to a range of full-field stimuli were recorded from 13-day-old (n = 8) and 18-day-old (n = 10) rats with a history of intermittent exposure to 80% oxygen and age-matched controls. The a-waves were fitted with a model of rod cell sensitivity and saturated response amplitude. The amplitudes and implicit times of the b-wave and oscillatory wavelets were examined as a function of stimulus energy. Response parameters in oxygen-exposed rats were compared to those in controls. RESULTS: The amplitude of the saturated rod response was reduced in oxygen-exposed 13-day-old but not 18-day-old rats. The sensitivity of the rod response was reduced in both 13- and 18-day-old oxygen-exposed rats. The saturated amplitude and sensitivity of the b-wave did not differ significantly between oxygen-exposed and control rats age 13 days, but both amplitude and sensitivity were significantly decreased in 18-day-old oxygen-exposed rats. Oscillatory potentials, which could be investigated only in 18-day-old rats, showed significant attenuation of OP3 but not OP4 amplitudes in the oxygen-exposed rats. The sensitivity of OP2 did not differ significantly between oxygen-exposed and control rats. The avascular area in the oxygen-exposed rats was not correlated with any of the rod cell, b-wave, or oscillatory potential response parameters. CONCLUSION: The function of the rod photoreceptors, as well as the inner retina, is altered in infant rats with a history of oxygen exposure. |
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Authors:
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X Reynaud; R M Hansen; A B Fulton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: 36 ISSN: 0146-0404 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 1995 Sep |
Date Detail:
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Created Date: 1995-10-02 Completed Date: 1995-10-02 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2071-9 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Childen's Hospitalk, Boston, MA 02115, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aerobiosis Animals Animals, Newborn Electroretinography / drug effects Humans Infant, Newborn Neurons / drug effects, physiology Oxygen / toxicity* Rats Rats, Sprague-Dawley Retina / drug effects, physiology* Retinal Rod Photoreceptor Cells / drug effects, physiology Retinopathy of Prematurity / etiology, physiopathology* |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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