Document Detail


Effect of prior exercise on thermal sensitivity of malignant hyperthermia-susceptible muscle.
MedLine Citation:
PMID:  20544946     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Malignant hyperthermia (MH) episodes may occur upon exposure to halogenated anesthetics, during resistance and endurance exercise, and in response to thermal stress. The purpose of this study was to investigate the effects of prior eccentric and concentric (i.e., wheel running) exercise on the thermal sensitivity of isolated MH-susceptible mouse muscle (RyR1(Y522S/wt)). Eccentric, but not concentric, exercise attenuated the thermal sensitivity of MH-susceptible muscle.
Authors:
Benjamin T Corona; Susan L Hamilton; Christopher P Ingalls
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Muscle & nerve     Volume:  42     ISSN:  1097-4598     ISO Abbreviation:  Muscle Nerve     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-08-17     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  270-2     Citation Subset:  IM    
Affiliation:
Department of Kinesiology & Health, PO Box 3975, Georgia State University, Atlanta, Georgia 30302-3975, USA.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Disease Susceptibility
Malignant Hyperthermia / genetics,  physiopathology*
Mice
Mice, Transgenic
Muscle Contraction*
Muscle, Skeletal / physiopathology*
Physical Conditioning, Animal*
Grant Support
ID/Acronym/Agency:
AR-41802/AR/NIAMS NIH HHS; R01 AR041802/AR/NIAMS NIH HHS; R01 AR041802-16/AR/NIAMS NIH HHS; R01 AR053349/AR/NIAMS NIH HHS
Comments/Corrections

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